GENETIC EPIDEMIOLOGICAL STUDIES OF NASOPHARYNGEAL CANCER

Project Details

Description

Nasopharyngeal carcinoma (NPC) is a rare disease in most countries
throughout the world (1/100,000), but it occurs at up to a 100-fold
higher frequency in the Chinese people of southern China and
Southeast Asia. The high incidence also appears in immigrant
Chinese. Family history is known to be a very important risk factor
for NPC. To investigate the potential genetic component for
susceptibility, a family study of NPC was carried out in Taiwan by
Dr. Yue-Fen Wang prior to joining the MEDIB. Detailed information
about family history of cancer, smoking habits, and consumption of
salted fish during childhood was collected from 750 NPC probands.
Segregation analysis of a truncated trait with a logistic probability
density function for age of onset was performed. Results suggest
that familial clustering of NPC can be best explained by a Mendelian
recessive locus with gender specific susceptibility, where
consumption of salted fish during childhood and the number unaffected
preceding sibs also affects risk. Under this model, the frequency of
the high risk allele was 0.18, and the lifetime susceptibility of NPC
was 0.09 for females and 0.18 for males with the high risk genotype.
Penetrance of this putative highrisk genotype by age 80 is 8% for
females and 16% for males, compared to 0.04% for females and 0.07%
for males with low risk genotypes. Individuals who consumed salted
fish during childhood have a slightly higher penetrance (8.8% for
females, and 17.2% for males by age 80 for the high risk genotype).
The best-fitting model suggests that the high risk gene accounts for
over 90% of NPC in this population.
StatusNot started

Funding

  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research

ASJC

  • Medicine(all)
  • Dentistry(all)
  • Genetics
  • Oncology
  • Cancer Research
  • Epidemiology

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