Project Details


While Los Angeles currently ranks third in AIDS cases among U.S.
cities, few cases are linked to intravenous drug use (IVDU). Of
the 3459 AIDS cases reported as of July 31, 1987, 93% were
homosexual or bisexual men and only 89 cases (2.6%) were
reported where IV drugs use was the sole risk factor. The proposed project is a 4-year longitudinal study tracing the
course of human immunodeficiency virus (HIV) infection in 450
intravenous drug users in Los Angeles County. The study will
relate individual characteristics and behaviors to the development
of seropositive status and assess the likelihood of diffusion to
heterosexual IVDUs. Four groups of narcotics IVDUs will be
assessed: men and women subdivided by those with and those
without a self-reported history of homosexual experiences in the
past 8 years. The specific aims of this project include the annual monitoring
over 3 years of (1) rate of change and diffusion of HIV infection in
the 4 specified subpopulations; (2) HIV antibody seroprevalence
and seroconversion among whites, blacks, and Mexican Americans;
(3) to determine knowledge about and attitudes toward AIDS, and
level of exposure to education and prevention efforts among the
groups studied; (4) to assess self-reported behaviors linked to
AIDS transmission; (5) to distinguish between the seropositive and
seropositive groups by demographic background, AIDS-related
knowledge, attitudes, and risk behaviors; (6) to evaluate the
effectiveness of AIDS education and prevention programs; (7) to
determine which behaviors predispose an IVDU to continue high
risk behaviors despite education and intervention efforts; (8) to
monitor the natural history and ARC and AIDS among HIV
infected individuals; (9) to gather information useful for the
subpopulations studied in planning for prevention, health care, and
medical service resource needs. A semi-structured interview will obtain demographic information,
drug and sexual histories, and frequency of high risk behaviors, as
well as open ended responses to other AIDS-related questions.
Analyses will be conducted and findings reported after each wave
of data collection.
Effective start/end date12/31/899/30/96


  • National Institute on Drug Abuse
  • National Institute on Drug Abuse
  • National Institute on Drug Abuse


  • Infectious Diseases
  • Medicine(all)
  • Neuroscience(all)


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