INHIBITION OF TUMOR CIRCULATION AND METABOLITE UPTAKE

Project Details

Description

Previous work has provided evidence that sodium cyanate and colchicine can
inhibit circulation and metabolite uptake in hepatomas under conditions in
which there is little or nor effect in normal tissues. The proposed
research is aimed at increasing our understanding of the nature of
compounds which can exert such effects and establishing conditions which
will give maximum selective effects on neoplastic tissues. The action of
organic isocyanates will be studied to see if they can influence metabolite
uptake in tumors. Comparisons will be made between nitrosoureas with
differing degrees of carbamoylating activity to determine if this activity
can be related to inhibition of metabolite uptake. Preliminary studies on
combination chemotherapy of murine melanoma will be extended to explore
potential synergistic effects of cyanate with other agents. The potential
value of cyanate in selective rescue protocols for cancer chemotherapy will
be investigated.
StatusFinished
Effective start/end date1/1/901/1/90

Funding

  • National Cancer Institute
  • National Cancer Institute

ASJC

  • Oncology
  • Cancer Research

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