Project Details


DESCRIPTION (from the application):

This application is for support for a Gordon Research Conference (GRC) on
Wound Repair, to be held from June 8-13, 1997. This will be the third GRC
on this topic. The first GRC (1993) had 95 attendees; the second (1995) had
over 100; the 1997 conference should approach the attendance limit of 135.
Wound repair is a fundamental, complex biological phenomenon essential to
host survival. Elucidation of the mechanisms by which wounds heal provides
insights into such diverse processes as embryogenesis, vasculogenesis,
inflammation, fibrosis, and solid tumor development. The field of wound
repair has undergone an explosive phase of modernization in the face of
recent discoveries in the areas of cell-cell and cell-matrix interactions,
and of cytokines/growth factors and their mode of signal transduction. The
possibilities of controlling aberrant wound repair through the exploitation
of these basic advances, including the potential for gene therapy, is now
clearly a reality. While there are a number of forums that convene to
address topics in the wound repair field, the GRC provides a unique and
intimate atmosphere for the exchange of state-of-the-art information. The
1997 conference will deal with aspects of the inflammatory response, and the
mechanisms involved in the interactions of inflammatory cells and platelets
with fibrinogen/fibrin in the blood coagulation process. The role of
cytokines and growth factors and their receptors in controlling cell
proliferation, extracellular matrix (ECM) deposition and angiogenesis will
be discussed. The role of the interactions between epithelial cells,
mesenchyme and ECM in repair processes will be addressed, and the intriguing
biology of the fetal wound healing process and the nature and role of stem
cells in repair will be addressed. Finally, there will be a session
considering the role of endotoxin in activating host defense mechanisms.
Clearly, understanding the mechanisms involved in repair, and elucidating
the nature of the complex molecular and cellular interactions that take
place in wounds will have far reaching implications. The GRC presents an
important forum for stimulating discussion on the biology of wound repair,
and it is to this end that we seek support.
Effective start/end date6/1/975/31/98


  • National Institute of Arthritis and Musculoskeletal and Skin Diseases


  • Cell Biology


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