MAPPING OF CLEFT LIP AND PALATE IN MICE

Project Details

Description

The human/mouse homology map provides an excellent tool to identify
candidate genes involved in human disease. Studies have been
initiated using several newly identified loci in man that are
candidates for involvement in facial clefting. In collaboration with
Dr. Erikson, we have used markers for homologous positions in the
mouse to search for QTLs affecting facial clefting. The search
identified a region of mouse chromosome 3 homologous to human 1q21 as
increasing liability to sporadic CL(P) when the A/J strain allele is
present. This effect might be expected since the A/J strain has much
higher incidence of sporadic CL9P) than does the C57B16J strain, the
other progenitor strain of the RI lines.
StatusNot started

Funding

  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research

ASJC

  • Medicine(all)
  • Dentistry(all)
  • Genetics

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