Two-component regulatory (TCR) systems are signal transduction pathways that provide organisms with information about its surroundings. We have created a library of Staphylococcus aureus mutant strains that contain individual deletions in the genes that encode two-component regulatory systems. We will use phenotypic analysis to determine if any of the strains in our mutant library have alterations when responding to cellular stressors or differ in virulence factor production. Strains that display phenotypes different from the wild-type will be further analyzed using classical and molecular genetics.
|Effective start/end date||10/1/10 → 9/30/17|
- National Institute of Food and Agriculture (National Institute of Food and Agriculture (NIFA))