MATHEMATICAL MODELS OF H PYLORI GASTRIC COLONIZATION

Project Details

Description

DESCRIPTION (Adapted from the Applicant's Abstract): Helicobacter pylori, a
gram negative bacteria that colonize the human stomach, are associated with
diseases of the upper gastrointestinal tract. Examination of the selective
pressures on H.pylori provide a model for host interactions with resident flora
since (I) H.pylori strains are highly diverse, and continued variation is
occurring during colonization of a single host; (ii) H.pylori strains lack SOS
repair, are naturally competent, and have substantial ability to exchange DNA
with other H.pylori cells, providing opportunities for the observed
"quasi-species" development; (iii) H.pylori Lewis expression varies during
colonization and host characteristics selected for particular phenotypes; (iv)
molecular loci have been identified that are involved in Lewis variation, and
mouse models have been developed in which variation can be predictably
observed; (v) Mathematical models have been developed for H.pylori colonization
in general and the dynamics of Lewis expression can be measured and develop a
model to predict its behavior. The specific aims are (1) To construct an
experimental rodent model for assessing population genetic changes in H.pylori
during gastric colonization of a single host, and to develop a deterministic
mathematical model that is representative and predictive. (2) To assess the
effects on variation of prior host phenotype, inoculum size, bacterial mutation
rate, and host immunological response on H.pylori population dynamics,
phenotypes, and genotypes to better identify the parameters of the mathematical
model. (3) To examine the effect of recombination between two different
H.pylori strains during experimental infections, and to develop representative
mathematical models for this more complex phenomenon.
StatusFinished
Effective start/end date9/1/008/31/15

Funding

  • National Institute of General Medical Sciences: $287,449.00
  • National Institute of General Medical Sciences: $191,999.00
  • National Institute of General Medical Sciences: $193,123.00
  • National Institute of General Medical Sciences: $256,013.00
  • National Institute of General Medical Sciences: $264,891.00
  • National Institute of General Medical Sciences: $168,703.00
  • National Institute of General Medical Sciences: $277,646.00
  • National Institute of General Medical Sciences: $197,111.00
  • National Institute of General Medical Sciences: $286,524.00
  • National Institute of General Medical Sciences: $277,517.00
  • National Institute of General Medical Sciences: $290,353.00
  • National Institute of General Medical Sciences: $256,624.00
  • National Institute of General Medical Sciences: $198,000.00

ASJC

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Applied Mathematics
  • Genetics
  • Mathematics(all)
  • Microbiology

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