Free fatty acids (FA) and monoacylglycerol (MG) are the hydrolysis products of dietary triacylglycerol (TG). They constitute not only a major source of calories, but are also precursors of many biologically active molecules and are incorporated as structural components of cellular membranes. The mechanisms which regulate the uptake and intracellular movement of FA and MG in intestinal cells remain largely unresolved. The ultimate goal of this work is to understand and thereby be able to regulate the influx, efflux, and intracellular targeting of FA and MG. This research will define the mechanisms by which dietary fat is taken up and processed by intestinal cells, and will provide an understanding of how the uptake of lipid can be regulated-either to decrease uptake, as in the case of caloric reduction, or to increase uptake, in the case of nutrient malabsorption. Such an understanding will not only enhance our knowledge of the basic mechanisms of utilization of a major nutrient, triacylglycerol, but will enable more effective regulation of net intestinal lipid uptake. This will have important implications for the treatment of obesity and malabsorptive disorders, and will assist in the development of effective enteral drug delivery systems.
|Effective start/end date||10/1/09 → 9/30/14|
- National Institute of Food and Agriculture (National Institute of Food and Agriculture (NIFA))
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