MEDIAL NUCLEUS OF THE TRAPEZOID BODY--IN VITRO STUDIES

  • Diehl, Scott (PI)
  • Friedman, Thomas Baer (PI)
  • Zook, John (PI)
  • Nance, Walter Elmore (PI)
  • Hutson, Kendall (PI)
  • Kiang, Nelson (PI)
  • Braida, Louis (PI)
  • Delgutte, Bertrand (PI)

Project Details

Description

Goals. The candidate's basic goal is to understand the function of the
descending, or efferent neural pathways in the auditory system. The
immediate goal is to characterize the interaction between ascending and
descending auditory systems at the level of the superior olivary
complex. Research Project. To further these objectives, a robust in vitro
preparation of the auditory brainstem has been developed using a mammal
with unusual metabolic tolerances, the brown bat, Eptesicus fuscus.
This slice preparation opens a difficult brainstem area to detailed
study, allowing axons and cells to be intracellularly labeled in
previously unattainable number and clarity. The initial project focus
is the medical nucleus of the trapezoid body (MNTB), a superior olivary
nucleus implicated in the circuitry of both ascending and descending
systems. Intracellular labeling suggests that both the cells of the
MNTB and the large ascending axons which contact these cells send
collateral projections to several common targets. One important target
is the periolivary cell group which forms the olivocochlear bundle, the
principle descending auditory tract of the brainstem. The slice
preparation is well suited to characterize this pivotal juncture between
ascending and descending auditory systems. Effect of RCDA. This award will permit a sustained and concentrated
effort toward the project goals. The award will also greatly enhance
the candidate's opportunities to refine the brainstem tissue slice
preparation and to develop the range of technical skills necessary to
achieve these goals. Institution's Plans. Ohio University has pledged strong support of the
candidate's research career development, in such forms as a vital
research environment, continued encouragement of intra- and extramural
collaborative interactions, and extensive research staff support and
facilities.
StatusActive
Effective start/end date9/1/896/30/22

Funding

  • National Institutes of Health: $331,401.00
  • National Institutes of Health
  • National Institutes of Health: $263,433.00

ASJC

  • Medicine(all)
  • Neuroscience(all)

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