Mitochondrial Mechanisms, Microvascular Function, and Gestational Nanotoxicology

Project Details


? DESCRIPTION (provided by applicant): Maternal homeostasis and the fetal milieu are highly susceptible to a variety of external or environmental exposures during gestation (e.g. malnutrition, toxicant exposure). Any dysfunction within the coordinated exchange of nutrients and waste during gestation could create a hostile gestational environment (HGE), leading to devastating fetal consequences. It has been hypothesized that fetal development within a HGE could be an underappreciated etiology for adult disease and/or sensitivity. Mitochondrial inefficiency has been theorized as one mechanistic link between development within a HGE and the development of adult disease. The continued development of engineered nanomaterials (ENM) (
Effective start/end date2/1/151/31/17


  • National Institute of Environmental Health Sciences: $86,157.00
  • National Institute of Environmental Health Sciences: $86,157.00


  • Cardiology and Cardiovascular Medicine


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