Project Details


DESCRIPTION: The long-term objective of the proposed study is to understand
the molecular mechanisms underlying the carcinogenic process of breast
cancer. The hypothesis to be tested is that the high morphological
heterogeneity associated with breast cancer development is a reflection of
different molecular pathways involved in the carcinogenic process. To test
this hypothesis, a systematic study of genome-scale analysis is required.
For this purpose, 600 genetic markers covering the entire human genome will
be identified. The markers will be incorporated into a multiplex genotyping
system with which 2,880 genotypes per day will be easily determined by one
investigator using the materials from microdissection. This system will be
used to examine the loss of heterozygosity (LOH) at all marker loci in all
common forms of invasive breast carcinomas and to examine tumor suppressor
genes (TSGs) involved in different pathways. Different pathways will be
compared to determine the TSGs that are commonly involved in the
carcinogenic process and those that are responsible for the morphological
features. All common breast lesions that have been considered as precursors
of breast cancer will also be included in the study so that the involvement
of TSGs at different stages of the corresponding pathways can be examined.
The resulting data will also be used to locate the chromosomal regions where
chromosomal breakage and/or somatic recombination occur frequently, to
identify reliable prognostic markers, and to provide molecular information
for curing the disease.
Effective start/end date4/1/981/31/02


  • National Cancer Institute
  • National Cancer Institute: $33,254.00
  • National Cancer Institute


  • Oncology
  • Cancer Research


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