• Marlink, Richard (PI)
  • Hsieh, Chung Cheng (PI)
  • Lallemant, Marc (PI)
  • Kanki, Phyllis (PI)

Project Details


Our preliminary data on the biology of HIV-2 suggest that this virus may
have a distinct biology from HIV-1. It is relevant, therefore, to assess
these differences in populations infected with significant rates of both
HIV-2 and HIV-1. Senegal is such a West African country and the
collaboration already established with investigators there provides a
strong base for future research. The prolonged incubation period for HIVs
in general suggests that much can be learned from the evaluation of
infected individuals over time. This would include: 1) the dynamics and
risk factors for transmission, 2) the immune response parameters evaluated
over the course of infection and their correlation with viral burden and
clinical course and 3) the evolution of HIV pathogenesis. Thus, natural
history studies of HIV viruses in general will provide the richest source
of information on risks for transmission, course of infection and evolution
of disease. At present, the transmission and natural history of HIV-2 in pediatric
populations are areas in need of further study. Project 1 will seek to
provide important information on risk factors and the rate of perinatal
transmission of HIV-2 in direct comparison to HIV-1. We will explore
various antibody and DNA markers of infection for both early diagnosis and
prognostic markers and correlate these with clinical course and outcome in
perinatally infected infant. Project 3 will provide more information on HIV in pediatric groups by
evaluating prevalence and disease association in children at high risk for
exposure to the virus. In this sentinel group survey we hope to learn more
about the risk factors for HIV infection in children. This project will
also provide valuable information on the natural history of HIV-2 infection
in older children. Since HIV disease evolution would be expected to progress more rapidly in
pediatric populations, Projects 1 and 3 will also contribute to our
understanding of the comparative pathogenic potentials of HIV-2 and HIV-1.
This will be concurrently addressed in the proposed studies of Project 2.
This will study disease evolution with HIV in adults by first surveying all
AIDS-like disease presentations and evaluating for the strength of
association with HIV-1 and HIV-2. By following infected individuals over
time we hope to study the clinical course of HIV-2 and HIV-1 disease from
initial presentation and evaluate immunologic and serologic parameters that
may be of prognostic value. The full characterization of HIV-2 infection
in these populations should provide the basis for evaluating therapeutic
and preventative strategies in the future.
Effective start/end date9/30/907/31/95


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)
  • Immunology and Microbiology(all)

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