NATURAL HISTORY OF PERINATALLY ACQUIRED HIV INFECTION

  • Marlink, Richard (PI)
  • Hsieh, Chung Cheng (PI)
  • Lallemant, Marc (PI)
  • Kanki, Phyllis (PI)
  • Marlink, Richard (PI)
  • Kanki, Phyllis J. (PI)
  • Kanki, Phyllis (PI)
  • Lallemant, Marc (PI)
  • Kanki, Phyllis (PI)
  • Hsieh, Chung Cheng (PI)

Project Details

Description

Senegal is a West African country with significant rates of both HIV-2 and
HIV-1 infection. In sub-Saharan Africa, sexually active women of child-
bearing age are considered at risk for both HIV-1 and HIV-2. There is a
tremendous need to better understand perinatal transmission and its
potential effect on pediatric populations. Currently, there is little data
available on perinatal transmission and the natural history of perinatally
acquired HIV-2 infection. Our proposed studies hope to provide more
information on HIV-1 and HIV-2 perinatal transmission and disease
development. This will provide important data needed to devise health
strategies for the prevention of HIV infection.

A. SPECIFIC AIMS:

(1) To determine the risk factors an rate of perinatal transmission for
both HIV-2 and HIV-1.

(2) To determine if mother and infant antibody responses to various HIV
antigens or epitopes may be useful in distinguishing passive from active
antibodies in infants (
StatusFinished
Effective start/end date1/1/017/31/95

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Infectious Diseases
  • History and Philosophy of Science
  • Virology
  • Pediatrics, Perinatology, and Child Health