NEURAL CORRELATES OF EMOTION

Project Details

Description

Two Pet studies are proposed to elucidate the specific contributions
of the orbitofrontal cortex (OFC) and amygdala to olfactory and
hedonic processing in humans. Study 1 examines whether activity
in the amygdala, OFC and pyriform cortex varies in a concentration
dependent manner. 15 subjects will be exposed to four
concentrations of butanol and four concentrations of phenylethyl
alcohol while cerebral blood flow (rCBF) is measured with PET.
Study I also examines whether attention modulated rCBF) is
measured with PET. Study 1 also examines whether attention
modulated rCBF in these regions by imaging subjects while attend
to and ignoring ordorants. In study 2,25 subjects will be exposed
to highly aversive, pleasant and neutral stimuli to examine if rCBF
in the OFC and amygdala varies with the hedonic meaning or
emotional responses induced by odorants. These studies represent
the first steps in a research program aimed at elucidating the
functions of the OFC and amygdala in humans, with a long-term
goal of determining the role of these structures in normal and
abnormal emotional behavior.
StatusFinished
Effective start/end date7/1/9710/31/99

Funding

  • National Institute of Mental Health
  • National Institute of Mental Health
  • National Institute of Mental Health

ASJC

  • Neuropsychology and Physiological Psychology
  • Social Sciences(all)

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