NEUROCOGNITIVE IMPAIRMENT AND ALCOHOL USE DISORDERS

Project Details

Description

More than half of alcoholics show diffusely distributed
neurocognitive impairment at treatment entry. Brain dysfunction
usually is not permanent following cessation of use. However,
there are individual differences in extent and rate of recovery.
This beterogeneity of deficit and of recovery rates suggests that
the longitudinal assessment of neurocognitive impairment across
multiple domains of functioning is needed to more adequately
study the relationship of impairment to outcome following
treatment. The goal of this proposal is to obtain funds to complete
a computerized data base and planned analyses of the impact of
neurocognitive impairment on treatment outcome using
longitudinal data previously collected in four treatment outcome
studies of alcohol use disordered individuals. Variables assessing
predictor and outcome constructs were collected prospectively
during the first week of treatment and on three additional
occasions spanning 12 mon. The obtained sample was
demographicaIly diverse. 217 individuals completed the battery at
treatment entry. By imputing data for subjects missing no more
than one of the three re-assessments, we will be able to analyze
longitudinal data for 81 % of the subjects at 6 wks and 70% of the
subjects at 6 and 12 mons. We propose to conduct descriptive
analyses of short- and long-term patterns of stability and change in
neurocognitive functioning both at the level of manifest variables
and broader constructs representing four major domains of
functioning: verbal abilities, memory, abstract reasoning/executive
functioning, and perceptual/motor skills. Prototypical
neurocognitive recovery groups based on initial level and
intraindividual changes in neurocognitive functioning over time
will be described. Relevant subject characteristics (e.g., age, sex,
and familial alcoholism history) will be examined as predictors of
differences in initial level and growth trajectories of
neurocognitive performance. Differences in initial level and in
subsequent changes in neurocognitive functioning will be tested as
predictors of short-term (i.e., 6 wks) and longer term (i.e., 6 and
12 mon) treatment outcomes. In a subset of the data (N= 122),
we will also test whether initial level and change in neurocognitive
functioning moderate the effects of treatment process variables on
treatment outcome, and whether their relation differs between
those with an alcohol only, other drug only, or alcohol and other
drug use disorder. Growth curve trajectories of changes in
neurocognitive functioning, especially within the domains of
executive controliabstraction and memory, are hypothesized to
increase the prediction of treatment outcomes, over and above the
effects of initial impairment. Further, initial level and subsequent
changes in neurocognitive functioning are predicted to moderate
the relation of change process factors (e.g. self-efficacy) to
treatment outcomes.
StatusFinished
Effective start/end date9/1/9710/31/05

Funding

  • National Institute on Alcohol Abuse and Alcoholism: $182,120.00
  • National Institute on Alcohol Abuse and Alcoholism: $189,260.00
  • National Institute on Alcohol Abuse and Alcoholism: $182,120.00
  • National Institute on Alcohol Abuse and Alcoholism: $183,240.00
  • National Institute on Alcohol Abuse and Alcoholism
  • National Institute on Alcohol Abuse and Alcoholism

ASJC

  • Psychiatry and Mental health
  • Psychology(all)

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