Project Details


The candidate's long-term goal are to establish a laboratory with
recognized expertise in biomaterials development, peptide chemistry and
polymer chemistry. The candidate's work id focused on the design,
synthesis and characterization of new molecular structures. In the areas
of biomaterials research and polymer chemistry, the candidate is developing
new methods for the modification of the backbone of synthetic poly(amino
acids). His synthetic approach is based on the polymerization of alpha-L-
amino acids via their side chains, resulting in the incorporation of non-
amide bonds into the poly(amino acid) backbone. Such backbone-modified
"pseudo-poly(amino acids) have potential uses as biomaterials for medical
applications e.g. implantable devices, injectable drug carriers, and
biocompatible coatings or membranes. The physical and chemical properties
and the immunological and toxicological properties of pseudo-poly(amino
acids) will be characterized. In the area of peptide chemistry, the
candidate is exploring the possible use of urethane linkages as
pseudopeptide mimetics of the conventional peptide bond. As a model
system, a new cyclic pseudotetrapeptide has ben synthesized that contains
two urethane bonds as part of its ring structure.
Effective start/end date9/28/909/27/95


  • National Institutes of Health: $64,089.00
  • National Institutes of Health
  • National Institutes of Health: $69,120.00
  • National Institutes of Health: $57,980.00
  • National Institutes of Health


  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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