• Zarbl, Helmut (PI)
  • Essigmann, John (PI)
  • Fitts, Renee (PI)
  • Walker, Graham (PI)
  • Thilly, William (PI)
  • Samson, Leona (PI)
  • Loechler, Edward (PI)
  • Demple, Bruce (PI)

Project Details


A consortium of seven laboratories is proposed to focus the power of modern
molecular analysis and cell technology on the processes of genetic change
induced by environmental mutagenic agents. Each of these laboratories is experienced in developing and applying its
own peculiar set of genetic, cellular and molecular techniques to the study
of gene mutation in bacterial, yeast, rodent and human cells. These
techniques include means to measure the amount, identify the structure and
specify the position in DNA of a variety of mutagenic reaction products.
The consortium is also capable of isolating and characterizing novel
mutants in the process of mutagenesis and investigating the biochemical
genetics of constitutive and inducible responses to premutagenic damage in
such variant cells. The proposed relation would be particularly strong in
its ability to identify, isolate and sequence genes related to the
processes of mutagenesis and to study the role of the products of such
genes in the molecular biology of cell responses to mutagenic agents.
Effective start/end date9/27/858/31/99


  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health


  • Environmental Science(all)
  • Medicine(all)

Fingerprint Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.