NONPOLAR OLIGOSACCHARIDE CONGENER BINDING TO PROTEINS

Project Details

Description

Oligosaccharide-protein binding is implicated in several processes
including immune related responses, pathogenic invasion and tumor
metastasis. Carbohydrate binding inhibitors could lead to therapies for
these disease states. Inhibitor development has been slowed by the
unavailability of structrually modified complex sugars and continue to
be hampered by a lack of detailed understanding of which structural
features of the carbohydrate are important and how they affect binding
at the molecular level.

The studies proposed here focus on the inhibition of protein-
carbohydrate recognition to provide both insights into the binding
process and a rational approach to develop effective treatments. The
system to be probed is the binding of a human breast tumor antigen,
globo-H, to monoclonal antibody MBr1. The pioneering work of Prof.
Danishefsky at Memorial Sloan-Kettering has allowed access to complex
and modified oligosaccharides. Thus, the major advantages of focusing
on this system are that both synthetic routes to generate potential
inhibitors and assays to evaluate them are in place for rapid
advancement toward the research goals.
StatusFinished
Effective start/end date7/2/987/1/00

Funding

  • National Cancer Institute
  • National Cancer Institute

ASJC

  • Cancer Research

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