NOVEL LYSOSOMAL ENZYME DEFICIENT IN BATTEN DISEASE

  • Lobel, Peter (PI)
  • LOBEL, PETER (PI)
  • LOBEL, PETER (PI)
  • LOBEL, PETER (PI)
  • LOBEL, PETER (PI)

Project Details

Description

DESCRIPTION: This is a project to determine the molecular basis of the late
infantile form of neuronal ceroid lipofuscinosis (LINCL). The starting
point is the successful cloning of the cDNA and determination of mutations
in the CLN2 protein. The specific aims are to (1) determine the structure
of the gene; (2) Identify mutations in the CLN2 gene; (3) develop a mouse
model of the disease; and (4) characterize the CLN2 protein and its
function.
StatusActive
Effective start/end date4/1/985/31/21

Funding

  • National Institute of Neurological Disorders and Stroke: $130,000.00
  • National Institute of Neurological Disorders and Stroke: $429,000.00
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke: $347,813.00
  • National Institute of Neurological Disorders and Stroke: $313,031.00
  • National Institute of Neurological Disorders and Stroke: $259,281.00
  • National Institute of Neurological Disorders and Stroke: $204,408.00
  • National Institute of Neurological Disorders and Stroke: $369,313.00
  • National Institute of Neurological Disorders and Stroke: $369,313.00
  • National Institute of Neurological Disorders and Stroke: $267,061.00
  • National Institute of Neurological Disorders and Stroke: $360,634.00
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke: $50,000.00
  • National Institute of Neurological Disorders and Stroke: $350,175.00
  • National Institute of Neurological Disorders and Stroke: $429,000.00
  • National Institute of Neurological Disorders and Stroke: $344,335.00
  • National Institute of Neurological Disorders and Stroke: $30,000.00
  • National Institute of Neurological Disorders and Stroke: $345,625.00
  • National Institute of Neurological Disorders and Stroke: $369,313.00
  • National Institute of Neurological Disorders and Stroke
  • National Institute of Neurological Disorders and Stroke: $50,000.00
  • National Institute of Neurological Disorders and Stroke: $275,073.00

ASJC

  • Medicine(all)
  • Neuroscience(all)
  • Clinical Neurology
  • Neurology
  • Transplantation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Molecular Biology
  • Biotechnology

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