NUCLEIC ACID CONFORMATION, PROPERTIES AND INTERACTIONS

Project Details

Description

The present application of configurational statistics to model the
nucleic acids or polynucleotides provides an essential first step
in relating the subtle features of chemical architecture to the
unique physical and biological properties of these macromolecules.
Through a combination of molecular modeling, potential energy
calculations, and statistical mechanical analyses it is possible
to elucidate details of nucleic acid conformation and to provide
a rational understanding of observed experimental phenomena. The
primary objectives of the program are to classify and understand
the complex array of nucleotide conformers, to comprehend the
effects of primary chemical sequences on secondary and tertiary
structure, and to elucidate pathway of conformational transitions.
The combined computations should enhance our comprehension of both
polynucleotide extension and flexibility offering new structural
insight into conformation and the irregularities of various forms.
The chain statistics studies may also provide a molecular basis for
understanding the nature and flexibility of specifically
constrained structures such as small closed circles, loops, knots,
hairpins, bulges, and cruciforms.
StatusFinished
Effective start/end date8/1/775/31/09

Funding

  • National Institutes of Health: $263,741.00
  • National Institutes of Health
  • National Institutes of Health: $254,173.00
  • National Institutes of Health: $266,046.00
  • National Institutes of Health: $253,978.00
  • National Institutes of Health: $285,718.00
  • National Institutes of Health
  • National Institutes of Health: $284,674.00
  • National Institutes of Health: $248,321.00
  • National Institutes of Health
  • National Institutes of Health: $267,622.00
  • National Institutes of Health
  • National Institutes of Health: $257,581.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $222,111.00
  • National Institutes of Health: $251,601.00
  • National Institutes of Health

ASJC

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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