Project Details

Description

The primary goal of our research program continues to be the elucidation of
the principles that govern the ways in which mucleic acids fold and
interact with other molecules. We will do this by determining and
analyzing the crystal structures of selected oligonucleotides and
oligonucleotide/small molecule complexes. Our studies of DNA-small
molecule interactions will include: 1) the determination of the structure
of a complex between the drug actinomycin D and and a DNA fragment in an
attempt to understand the molecular basis for its antitumor and antibiotic
activities; 2) the determination of the structures of DNA fragments to
which the chemotherapeutic agent mitomycin C have been bound; and 3) the
determinations of structures of complexes between the chiral specific probe
RuDIP and left and right handed DNA. In addition we will be studing the
effects of sequence on the structure of DNA by determining the crystal
structures of several selected oligonucleotides.
StatusFinished
Effective start/end date12/1/775/31/11

Funding

  • National Institutes of Health: $128,449.00
  • National Institutes of Health: $364,348.00
  • National Institutes of Health: $301,635.00
  • National Institutes of Health: $295,494.00
  • National Institutes of Health
  • National Institutes of Health: $341,154.00
  • National Institutes of Health
  • National Institutes of Health: $369,185.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $231,750.00
  • National Institutes of Health: $286,846.00
  • National Institutes of Health: $313,894.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $282,293.00
  • National Institutes of Health
  • National Institutes of Health: $285,756.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $269,669.00
  • National Institutes of Health: $359,558.00
  • National Institutes of Health: $350,223.00
  • National Institutes of Health

ASJC

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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