ORAL ABSORPTION AND BIOPHARMACEUTICS OF ANTI-HIV DRUGS

Project Details

Description

DESCRIPTION: (Adapted from Applicant's Abstract). The long term
objective of this research is to provide a rational, mechanistic basis
for improving the oral therapy of nucleoside drug analogues effective
against HIV.The specific aims of the proposed research are: (1) To
investigate the intestinal absorption mechanism of anti-HIV nucleoside
analogues and to investigate the molecular basis for potential drug-drug
and drug-nutrient absorption interaction; (2) To investigate the
intestinal luminal, brush border and cytosolic metabolism and chemical
stability of nucleoside analogues; (3) To construct a database that can
be used for investigating the molecular-structural requirements of
nucleoside analog oral absorption;and (4) To develop predictive models
that will be used to correlate in vitro/in situ results with extent of
absorption data in humans and to develop models that will predict
bioavailability variability in humans. The investigator believes that the
results of the proposed research will further the understanding of the
factors that affect the oral efficacy of nucleoside drug analogues
allowing for efficient and rational drug design and that the mechanistic
insight gained will allow for improved and consistent nucleoside drug
therapy leading to a decrease in therapy limiting side effects, to less
variable systemic availability and blood levels and, ultimately, to
improved oral anti-HIV drug therapy.
StatusFinished
Effective start/end date12/1/9211/30/98

Funding

  • National Institute of Allergy and Infectious Diseases
  • National Institute of Allergy and Infectious Diseases
  • National Institute of Allergy and Infectious Diseases
  • National Institute of Allergy and Infectious Diseases
  • National Institute of Allergy and Infectious Diseases

ASJC

  • Pharmacology

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.