OUTPATIENT NURSE MANAGED HIV ADHERENCE TRIAL

Project Details

Description

DESCRIPTION (Adapted from Applicant's Abstract): Highly active antiretroviral
therapy (HAART) that includes a protease inhibitor has led to significant
reductions in HIV-related morbidity and mortality. However, the challenge of
adhering to HAART therapy is immense. This revised application proposes a
randomized clinical trial to test a standardized HAART adherence intervention
program, Client Adherence Profiling-Intervention Tailoring (CAP-IT),
implemented by nurse case managers during regularly scheduled home visits, for
clients (n=222) newly admitted in the AIDS Case Management Program, Office of
AIDS, State of California. CAP-IT is an innovative, structured nursing
assessment and care planning activity that allows a standardized assessment of
client needs and tailored HAART intervention strategies. CAP-IT is
significantly different from the current standard nursing case management
practice. The study aims are: 1) To test if a standardized adherence
intervention program, compared to standard care, results in improved HAART
adherence rates; 2) To test if a standardized adherence intervention program,
compared to standard care, impacts CD4 count, viral load, and HAART resistance;
3) To test if there is a relationship between adherence and CD4 count, viral
load, and HAART resistance; 4) To test if a standardized adherence intervention
program, compared to standard care, impacts clients' quality of life; and, 5)
To test if a standardized adherence intervention program, compared to standard
care, impacts health-related resource utilization. The review of the literature
supports the significance of the issue of adherence to HAART therapy and the
need for further research focused on the effectiveness of interventions aimed
at improving adherence and subsequent health-related outcomes. Evidence is also
provided to support the feasibility of utilizing nurse case managers to
delivery a home care-based adherence intervention.
StatusFinished
Effective start/end date9/30/992/28/05

Funding

  • National Institute of Nursing Research: $151,788.00
  • National Institute of Nursing Research: $248,423.00
  • National Institute of Nursing Research: $584,714.00
  • National Institute of Nursing Research: $64,113.00
  • National Institute of Nursing Research: $433,302.00
  • National Institute of Nursing Research
  • National Institute of Nursing Research: $161,224.00

ASJC

  • Public Health, Environmental and Occupational Health
  • Nursing(all)

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.