POLYMERS DESIGNED FOR BIOMEDICAL APPLICATIONS

Project Details

Description

The underlying rationale of this proposal is that once suitable
structure-property correlations have been established for a class of
polymers, it is possible to design in a systematic fashion materials for
specific applications. This general approach will be applied to the
design of pseudo-poly(amino acids) - a new class of amino acid containing
polymers. The specific objectives of this proposal are threefold: (a)
to continue the synthetic exploration of pseudo-poly(amino acids) by the
preparation of polyarylates containing derivatives of L-tyrosine; (b) to
establish detailed correlations between polymer structure and polymer
properties; and (c) to explore whether well-characterized polymeric
surfaces can be used to investigate some of the parameters that
influence the complicated interactions between a polymer and living
cells. In the first phase of the proposed program, optimized synthetic
techniques for the preparation of polyarylates from derivatives of L-
tyrosine and naturally occurring diacids will be developed. The proposed
polyarylates will have backbone elements and pendent chains whose length
can be varied independently. This design provides a high degree of
control over the polymer structure, making these materials an ideal
system for the exploration of structure-property correlations. The
pendent chains will also be used for controlled surface
modifications. In the second phase, the proposed polyarylates will be
used as a test system for the investigation of correlations between the
polymer structure (on a molecular level) and macroscopic physico-
mechanical properties. In the third phase, an exploratory study of the
biological interactions of polyarylates with living cells will be
undertaken. These studies are a necessary prerequisite before new
polymers can be considered for potential human applications. The results obtained in this research program will contribute to a better
understanding of the material properties of amino acid derived polymers
and the interactions of these polymers with living cells. In the long-
term, this work will contribute to the development of polymeric
implant materials with improved biocompatibility. Possible future
"target applications" are the development of custom designed materials
for vascular grafts and/or stents.
StatusFinished
Effective start/end date8/1/937/31/98

Funding

  • National Institutes of Health
  • National Institutes of Health: $151,026.00
  • National Institutes of Health: $165,905.00
  • National Institutes of Health

ASJC

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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