PRINCIPAL NIH RESEARCH RESOURCE X RAY BEAMLINE AT NSLS: WIGGLER BEAMLINE X25

  • Arnold, Edward (PI)
  • Flanagan, John (PI)
  • Phillips, Walter (PI)
  • Berendzen, Joel (PI)
  • Moore, Peter B. (PI)
  • Berman, Lonny (PI)
  • Ealick, Steven (PI)
  • Capel, Malcolm (PI)
  • Ruiming, Xu (PI)
  • Reinherz, Ellis (PI)
  • Terwilliger, T.O.M. (PI)
  • Ellenberger, Tom E. (PI)
  • Sweet, Robert (PI)
  • Lewis, H.A.L. (PI)
  • Sanghani, Paresh (PI)
  • Ohlendorf, Douglas (PI)
  • Chen, L.I.N. (PI)
  • Mariuzza, Roy (PI)
  • Bahnson, Brian (PI)
  • Beese, Lorena (PI)
  • Hill, Christopher P. (PI)
  • Churchill, Mair (PI)
  • Doublié, Sylvie (PI)
  • van Roey, Patrick (PI)
  • Brown, Bernard Andrew (PI)
  • Patel, Dinshaw (PI)
  • Crane, Brian (PI)
  • Lu, Y.I. (PI)
  • Wolberger, Cynthia (PI)
  • Ha, Y.A. (PI)
  • Honglin, Li (PI)
  • Kantrowitz, Evan (PI)
  • Lambright, David (PI)
  • Kull, F. (PI)
  • Becker, Michael (PI)
  • Amzel, L. Mario (PI)
  • Reinisch, Karin (PI)
  • Steitz, Thomas Arthur (PI)
  • Crane, Ann (PI)
  • Gouaux, James Eric (PI)
  • MacKinnon, Roderick (PI)
  • Schneider, Dieter K. (PI)
  • Swaminathan, Subramanyam (PI)
  • Robinson, Howard (PI)
  • Gehring, Kalle (PI)
  • Marcotrigiano, Joseph (PI)
  • Quan, Hao (PI)
  • Leahy, Daniel (PI)
  • Agbandje-McKenna, Mavis (PI)
  • Stock, Ann M. (PI)
  • Bohm, Alex Andrew (PI)
  • Sondek, John (PI)
  • Muniz, Joao Renato Carvalho (PI)
  • Lawson, Catherine (PI)
  • Marmorstein, Ronen (PI)
  • Varughese, Kottayil (PI)
  • Wang, Jia Huai (PI)
  • Wucherpfennig, Kai (PI)
  • Richter-Addo, George Bannerman (PI)
  • Dashuang, Shi (PI)
  • Izard, Tina (PI)
  • Parry, Christian (PI)
  • Jiang, Jiming (PI)
  • Pollard, Thomas D. (PI)
  • Boriack-Sjodin, Ann (PI)
  • Kong, Xiangpeng (PI)
  • Silvaggi, Nicholas (PI)
  • Kissinger, Chuck (PI)
  • Schulman, Brenda (PI)
  • Neiditch, Matthew (PI)
  • Coulombe, Rene (PI)
  • Lolis, Elias (PI)
  • Ferguson, Kashae (PI)
  • Clarke, Teresa (PI)
  • Birrane, Gabriel (PI)
  • Verdine, Gregory (PI)
  • Cygler, Mirek (PI)
  • Murakami, Katsuhiko (PI)
  • Bruner, Steven (PI)
  • Hengming, Ke (PI)
  • Parris, Kevin Delos (PI)
  • Strobel, Scott (PI)
  • Sygusch, Jurgen (PI)
  • Ippolito, Joseph (PI)
  • Zhao, Yanxiang (PI)
  • Mallett, T. Conn (PI)
  • Williams, Loren D. (PI)
  • Cordes, Matthew (PI)
  • Jianhua, Fu (PI)
  • Soares, Alexei Suarez (PI)
  • Braddock, Demetrios (PI)
  • Colman, Peter (PI)
  • Zhaohui, Xu (PI)
  • McDonough, Michael (PI)
  • Kobe, Bostjan (PI)
  • Yili, Li (PI)
  • Serganov, Alexander (PI)
  • Gallagher, Travis (PI)
  • Morstein, Ronen (PI)
  • Delbaere, Louis (PI)
  • Paetzel, Mark William (PI)
  • Loll, Patrick (PI)
  • Samanta, Uttamkumar (PI)
  • Mariuzza, Roy (PI)
  • Moore, Peter B. (PI)
  • Cohen, Carolyn (PI)
  • Rould, Mark (PI)
  • Van Den Akker, Focco (PI)
  • Huang, Zhen (PI)
  • Merithew, Eric (PI)
  • Heroux, Annie (PI)
  • Goldberg, Jonathan (PI)
  • Miller, Christopher (PI)
  • Schlessinger, Joseph (PI)
  • Berman, Lonny E. (PI)
  • Jayaraman, Sivaraman (PI)
  • Yigong, Shi (PI)
  • Hill, Christopher P. (PI)
  • Birktoft, Jens (PI)
  • Hong, Li (PI)
  • Junop, Murray (PI)
  • Almo, Steven C. (PI)
  • Martucci, Walter E. (PI)
  • Howell, Patricia Lynne (PI)
  • Song, Jian (PI)
  • Quan, Hao (PI)
  • Zhao, R.U.I. (PI)
  • Royer, William (PI)
  • Fu, D.A.X. (PI)
  • Wang, Zhongmin (PI)
  • Hunt, John Francis (PI)
  • Schroeder, Susan (PI)
  • Kielkopf, Clara (PI)
  • Vivien, Yee (PI)
  • Kissinger, Charles (PI)
  • Bohm, Alex Andrew (PI)
  • Vicens, Carlos N. (PI)
  • Wucherpfennig, Kai (PI)
  • Morais Cabral, Joao (PI)
  • Ha, Y.A. (PI)
  • Smith, Paul (PI)
  • Blaber, Michael (PI)
  • Pata, Janice (PI)
  • Radisky, Evette (PI)
  • Bussiere, Dirksen (PI)
  • Reinisch, Karin (PI)
  • Hart, Peter John (PI)
  • Allen, Karen N. (PI)
  • Vedula, Lakshmi Sangeetha (PI)
  • Blobel, Günter (PI)
  • Schindelin, Hermann (PI)
  • Buchanan, Susan K. (PI)
  • Wang, Q.I. (PI)
  • Eckenroth, Brain (PI)
  • Zhou, Zhanxiang (PI)
  • Lowther, W. Todd (PI)
  • Gallagher, David (PI)
  • Simmons, Chad Robert (PI)
  • Zhaohui, Xu (PI)
  • Krasilnikov, Andrey S. (PI)
  • Robinson, Victoria (PI)
  • Silvaggi, Nicholas (PI)
  • Park, Richard (PI)
  • Huang, Mingdong (PI)
  • Hughson, Frederick (PI)
  • McMillan, Martin (PI)
  • Agbandje-McKenna, Mavis (PI)
  • Lawson, Catherine (PI)
  • Allen, Catherine (PI)
  • Hollis, Thomas (PI)
  • vandenberg, Laura N. (PI)
  • Anderson, Amy C. (PI)
  • Stern, Lawrence (PI)
  • Zongchao, Jia (PI)
  • Tang, Liang (PI)
  • Joseph, Lee (PI)
  • Parsons, James (PI)
  • Christopher Charles, Law (PI)
  • Tremblay, Lee (PI)
  • Serganov, Alexander (PI)
  • Neiditch, Matthew (PI)
  • Xiong, Yong (PI)
  • Acharya, Runa (PI)
  • Modis, Yorgo (PI)
  • Jiang-Yong, Min (PI)
  • Furukawa, Hiroyasu (PI)
  • Aggarwal, Aneel K. (PI)
  • Orville, Allen (PI)
  • Khangulov, Sergei (PI)
  • Morrison, James (PI)
  • Eathiraj, Sudharshan (PI)
  • Z Helen, Wu (PI)
  • Boudker, Olga (PI)
  • Jiang, Jianfei (PI)
  • Yuan, Y.U. (PI)
  • Sanghani, Paresh (PI)
  • Almo, Steven C. (PI)
  • Czyzewski, Bryan K. (PI)
  • Soares, Alexei Suarez (PI)
  • Quan, Hao (PI)
  • Pavletich, Nikola (PI)
  • Beglova, Natalia (PI)
  • Jogl, Gerwald (PI)
  • Akey, Christopher (PI)
  • Stock, Ann M. (PI)
  • Long, Stephen Barstow (PI)
  • Boriack-Sjodin, P. (PI)
  • Riedl, Stefan (PI)
  • Richter-Addo, George Bannerman (PI)
  • Pata, Janice (PI)
  • Oldfield, Eric (PI)
  • Wuxian, Shi (PI)
  • Lolis, Elias (PI)
  • Heldwein, Ekaterina (PI)
  • Schiffer, Celia A. (PI)
  • Joshua, Leemor (PI)
  • Howell, Patricia Lynne (PI)
  • Garcia-Diaz, Miguel (PI)
  • MacKinnon, Roderick (PI)
  • McKeever, Brian Michael (PI)
  • Huang, Zhen (PI)
  • Blaber, Michael (PI)
  • Radisky, Evette (PI)
  • Pascal, John (PI)
  • Page, Rebecca (PI)
  • Sliz, Piotr (PI)
  • vandemark, Andrew Paul (PI)
  • Smith, Paul Bradley (PI)
  • Reinisch, Karin (PI)
  • Christensen, Hans Erik (PI)
  • Jian, Hu (PI)
  • Schlessinger, Joseph (PI)
  • Mariuzza, Roy (PI)
  • Allen, Karen (PI)
  • Mangel, Walter F. (PI)
  • Hardy, Jeanne (PI)
  • Vedula, Lakshmi Sangeetha (PI)
  • Feklistov, Andrey (PI)
  • Bowman, Gregory Dean (PI)
  • Bing, Hao (PI)
  • Seeliger, Markus August (PI)
  • Armache, Karim Jean (PI)
  • Steitz, Thomas Arthur (PI)
  • Bruner, Steven (PI)
  • Everse, Stephen (PI)
  • Huang, Mingdong (PI)
  • Sherman, David (PI)
  • Bohm, Alex Andrew (PI)
  • Hubbard, Stevan R. (PI)
  • Blobel, Günter (PI)
  • Nimigean, Crina (PI)
  • Hang, Shi (PI)
  • Lawson, Catherine (PI)
  • Lu, Y.I. (PI)
  • Simanshu, Dhirendra (PI)
  • Fromme, J. Christopher (PI)
  • Gerratana, Barbara (PI)
  • Blacklow, Stephen C. (PI)
  • Liu, Chang (PI)
  • Zhou, Ming (PI)
  • Liu, Chang (PI)

Project Details

Description

For several years X25 arguably has been the most sought-after beamline in the United States. The fact that macromolecular crystallographic measurements have competed so well recently for access to this facility speaks to the importance of the likely result, and the quality of preparations made by the experimenters. However, partially because the users who win time on the beamline have been from the most experienced groups in the U.S., and partially because there has been too little personnel available for teaching and supervision of visitors, the beamline has run in a relatively primitive mode for PX: substandard detectors, software that does not go beyond simple operations, and little assistance from experienced crystallographers beyond initial training in operation of the beamline. Therefore, we will embark on this technological development project to establish apparatus, software, and methods that not only will enhance our ability to make measurements that are impossible on NSLS dip ole bearrilines, but also will make absolutely the most efficient use of this precious resource. To some extent, projects 1. 1 and 1.2 are a part of this - development of software and hardware. X25 becomes the focus point where all of these developments must come together to achieve the highest goals and to solve the most difficult biological problems.
StatusFinished
Effective start/end date9/30/986/30/13

Funding

  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health

ASJC

  • Medicine(all)

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