Project Details


Blood Transfusions, like all other medical treatments, should be
prescribed only after a careful consideration of the risks vs. the
benefits of the procedure. While there is much in the literature
concerning the potential risks associated with transfusions, little is
known about the indications and benefits of red cell transfusions. The
'10/30' (hemoglobin/hematocrit) threshold for transfusion has been widely
used until recently. The applicant is currently funded by NIH and AHCRR
to perform two different but highly complementary research projects. The
Anemia and Surgery study will determine the risk of death in relationship
to perioperative hemoglobin levels in 2,000 patients who refuse blood
transfusions for religious reasons. The Variation of Surgical Blood
Transfusion study will assess the effect of variation of blood
transfusion practices on the risk of death in 10,000 surgically repaired
hip fracture cases. While the studies will provide important insights
into transfusion practice and outcomes, the known limitations of
observational research necessitates the use of a randomized clinical
trial to truly define the risks and benefits of transfusions. During
this fellowship the applicant will 1) acquire training and experience
with clinical trials 2) will develop a research protocol to study the
efficacy of blood transfusions in the perioperative setting and 3)
begin organizing the clinical trial.
Effective start/end date9/19/95 → …


  • National Institutes of Health


  • Medicine(all)

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