Project Details


The objectives of this program are to improve the local control of hepatic
metastasis of colorectal carcinoma through intra-arterial or portal vein
chemotherapy. Clinical and laboratory studies are integrated so that leads
in the laboratory are followed up by clinical studies and vice versa.
memorial Sloan-Kettering Cancer Center has a sufficient number of patients
(approximately 125/year) who either have surgical resection of metastatic
colorectal cancer in the liver or hepatic artery catheters/implantable pump
placed, to allow these clinical studies to be done in a single institution.
The program includes Phase II and III studies of therapy (Project IA);
improved techniques for quantitating response (Project IB); laboratory
studies to assess natural and acquired resistance to fluorodeoxyuridine and
dichloromethotrexate (Project II); and a rat model system for assessing
toxicity and response to chemotherapeutic agents and protective agents
(Project III). Investigators participating in this project are from the
disciplines of medical oncology, surgery, radiation therapy, radiology,
radiation physics, developmental therapy and biostatistics.
Effective start/end date7/1/896/30/92


  • National Institutes of Health: $506,493.00
  • National Institutes of Health
  • National Institutes of Health


  • Medicine(all)

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