REGULATION OF CORONARY MICROVASCULAR FLOW AND TRANSPORT

Project Details

Description

Significant advances have been made in understanding the Cardiovascular
system. However, little attention has been given to the myocardial
microcirculation. We propose to study the regulatory mechanisms of
coronary microvascular flow and transport in health and in diabetes
mellitus. We will use intravital microscopy assisted by computer image
analysis to visualize the epimyocardial microcirculation. Morphometric
analysis will be performed also by light, scanning and electron microscopy
to determine structure-function relationships. The indicator dilution
method will be used to assess the overall transport capacity of the heart.
Diabetes mellitus will be chemically induced. The coronary microvascular
alterations in flow and transport will be investigated. Our results will
provide a basis to further understand the adaptive mechanisms by which the
coronary microcirculation meets myocardial metabolic demands and how these
control processes are altered by diabetes mellitus.
StatusFinished
Effective start/end date1/1/901/1/90

Funding

  • National Heart, Lung, and Blood Institute
  • National Heart, Lung, and Blood Institute

ASJC

  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

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