RISK FACTORS FOR DIABETIC RETINOPATHY IN BLACK AMERICANS

Project Details

Description

Diabetic retinopathy is responsible for approximately 15% of blindness
in the United States. Among Blacks, the prevalence of diabetes is high
and the incidence increasing; thus, diabetic retinopathy and associated
visual impairment represents a major public health problem for the U.S.
Black population. The overall goal of this study is to ascertain factors for developing
severe diabetic retinopathy (in order ultimately to identify patients who
are likely to develop the condition), in Blacks with type I (insulin
dependent) diabetes mellitus. In order to achieve this goal, we will
investigate the frequency of diabetic retinopathy using a graded
classification scheme, and relate retinopathy severity levels to several
specific risk factors. We hypothesize that presence and severity levels
of diabetic retinopathy in diabetic Blacks are significantly associated
with five putative risk factors: longer duration of disease, female
gender, poor glycemic control, high blood pressure, and low socioeconomic
status. The patient population for our study will be comprised of type I diabetic
Black patients, as identified from the New Jersey Hospital Discharge
Data. Clinical evaluation of patients will include ocular examination,
fundus photography, a structured clinical interview, and a dietary
questionnaire. Laboratory evaluation will include measurement of blood
and urine samples to assess glycemic control, insulin insufficiency,
diabetic renal disease, and blood antioxidant levels. Presence and
severity levels of diabetic retinopathy will be related to the risk
factors identified above. Diabetic retinopathy among Black diabetics is a condition in dire need
of investigation. Our proposed studies will yield the first
comprehensive data on severity levels of diabetic retinopathy and
contributive risk factors in type I Black diabetic patients.
Furthermore, it is expected that these data will provide a basis for
public health education strategies and treatment modalities to prevent
or reduce severity of diabetic retinopathy in all diabetic patients.
StatusFinished
Effective start/end date12/1/921/31/06

Funding

  • National Institutes of Health: $474,882.00
  • National Institutes of Health
  • National Institutes of Health: $38,875.00
  • National Institutes of Health: $473,006.00
  • National Institutes of Health: $433,494.00
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health
  • National Institutes of Health: $463,504.00
  • National Institutes of Health

ASJC

  • Medicine(all)

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