Role of cDC2 subsets in host protection and CD4T cell responses in melanoma

Project Details


Project Narrative CD4T cells are generally considered as the master regulator of adaptive immunity, but how CD4T cells are regulated in melanoma is poorly understood. In this grant application, we propose to directly examine the role of cDC2 cells, a conventional dendritic cell subset with high CD4T cell priming capacity, in CD4T cell activation in mouse models of melanoma. Our goal is to understand the basic mechanism of CD4T cell activation in melanoma and identify the critical cDC2 subsets and their molecular signatures that can potentially be future therapeutic targets.
Effective start/end date2/1/211/31/23


  • National Cancer Institute: $214,012.00


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