SPECT IMAGING NERVE TRANSPORTER SITES MPTP TREATED MONKEYS: PARKINSONS: BRAIN

  • Vatner, Stephen (PI)
  • Vatner, Dorothy (PI)
  • TOSTESON, DANIEL (PI)
  • Martin, Joseph (PI)
  • MADRAS, BERTHA (PI)
  • KINSEY, JANICE (PI)
  • JORGENSEN, MATTHEW (PI)
  • PLATT, DONNA (PI)
  • DEBLOIS, SANDRA (PI)
  • NOVAK, MELINDA (PI)
  • GRECH, DOREEN (PI)
  • BARRETT-LARIMORE, RITA (PI)
  • SPEALMAN, ROGER (PI)
  • KANTAK, KATHLEEN (PI)
  • RIBERDY, ANN (PI)
  • BERGMAN, JACK (PI)
  • Sato, Naoki (PI)
  • VATNER, STEPHEN (PI)
  • HEYNDRICKX, GUY (PI)
  • Kalthof, Bernd (PI)
  • BISHOP, SANFORD (PI)
  • Shen, You-Tang (PI)
  • Iwase, Mitsunori (PI)
  • HASEBE, NAOYUKE (PI)
  • LACKNER, ANDREW (PI)
  • SASSEVILLE, VITO (PI)
  • MANSFIELD, KEITH (PI)
  • SIMON, MEREDITH (PI)
  • JOHNSON, LORNA (PI)
  • Zhang, Da (PI)
  • Zhang, Da (PI)
  • Zhang, Da (PI)
  • ROSENZWEIG, MICHAEL (PI)
  • KAUR, AMITINDER (PI)
  • JOHNSON, PAUL (PI)
  • WILLIAMS, JL (PI)
  • DU, ZHENJIAN (PI)
  • DANIEL, MUTHIAH (PI)
  • Kirchhoff, Frank (PI)
  • MORRISON, HILARY (PI)
  • GIBBS, JAMES (PI)
  • JUNG, JAE (PI)
  • JUNG, JAE (PI)
  • LEE-PARRITZ, DAVID (PI)
  • JACKSON, LYNN (PI)
  • JACKSON, LYNN (PI)
  • DEWS, PETER (PI)
  • APOSHIAN, VASKEN (PI)
  • BARBAS, HELEN (PI)
  • BLASDEL, GARY (PI)
  • BORN, RICHARD (PI)
  • CARLSON, MARY (PI)
  • Chen, Zheng (PI)
  • DOGON, LEON (PI)
  • GWOSDOW, ANDREA (PI)
  • GENAIN, CLAUDE (PI)
  • Isacson, Ole (PI)
  • LETVIN, NORMAN (PI)
  • LU, YICHEN (PI)
  • NEER, ROBERT (PI)
  • Rakic, Pasko (PI)
  • RAVIOLA, ELIO (PI)
  • REIMANN, KEITH (PI)
  • RHOADS, DAVID (PI)
  • RINGLER, DOUGLAS (PI)
  • SAROFF, DANIEL (PI)
  • SPRINGER, TIMOTHY (PI)
  • Stewart, Caro Beth (PI)
  • SUSA, JOHN (PI)
  • TROILO, DAVID (PI)
  • GAUDIN, CHRISTOPHER (PI)
  • Litwin, Sheldon (PI)
  • KACIMI, RACHID (PI)
  • WANG, FREDERICK (PI)
  • DESROSIERS, RONALD (PI)
  • DESROSIERS, RONALD (PI)
  • SIDMAN, RICHARD (PI)
  • KING, NORVAL (PI)
  • SEHGAL, PRABHAT (PI)
  • SEHAGAL, PRABBAT (PI)
  • TOSTESON, DANIEL (PI)
  • DESROSIERS, RONALD (PI)
  • FERRELL, THOMAS (PI)
  • MORSE, WILLIAM (PI)
  • KING, NORVAL (PI)
  • DANIEL (PI)
  • PETTO, ANDREW (PI)
  • MADRAS (PI)
  • SPEALMAN (PI)
  • WETTSTEIN, JOSEPH (PI)
  • FUJII (PI)
  • Young (PI)
  • KNIGHT (PI)
  • SHEN (PI)
  • GELPI (PI)
  • MORITA (PI)
  • VATNER (PI)
  • KING (PI)
  • KING (PI)
  • RINGLER (PI)
  • MA (PI)
  • COLLINS (PI)
  • REIMANN (PI)
  • WATANABE (PI)
  • TSUBOTA (PI)
  • WATKINS (PI)
  • DESROSIERS, RONALD (PI)
  • YEN (PI)
  • PARK (PI)
  • YEN (PI)
  • DESROSIERS, RONALD (PI)
  • Y-T TUNG (PI)
  • AUSMAN (PI)
  • HUNT (PI)
  • LEE-PARRITZ (PI)
  • ROLLAND (PI)
  • PETTO (PI)
  • NOVAK (PI)
  • GODFREY (PI)
  • BIGGERS (PI)
  • BELINGER, LYNDA (PI)
  • CURRAN, JAMES (PI)
  • TOSTES TON, DANIEL (PI)
  • AUSMAN, LYNNE (PI)
  • TOSTESTON, DANIEL (PI)
  • HARTLEY, HOWARD (PI)
  • KELLEHER, ROGER (PI)
  • MA, NANCY (PI)
  • FALK, LAWRENCE (PI)
  • DORR, BRUCE (PI)
  • KING, NORVAL (PI)
  • NICOLOSI, ROBERT (PI)
  • HUNT, RONALD (PI)
  • GIROUARN, MARION (PI)
  • MERCIER, ARNOLD (PI)
  • BRAND, STEPHEN (PI)
  • ROSOL, THOMAS (PI)
  • SPEALMAN, ROGER (PI)
  • KHROYAN, TALINE (PI)
  • PLATT, DONNA (PI)
  • ROWLETT, JAMES (PI)
  • LUTZ, CORRINE (PI)
  • NOVAK, MELINDA (PI)
  • NOVAK, MA (PI)
  • SANDRA, DEBLOIS (PI)
  • LACKNER, ANDREW (PI)
  • JOHNSON, LORNA (PI)
  • SIMON, MEREDITH (PI)
  • Chen, Zheng (PI)
  • REIMANN, KEITH (PI)
  • SHANNON, RICHARD (PI)
  • SASSEVILLE, VITO (PI)
  • VEAZEY, RONALD (PI)
  • WILLIAMS, KENNETH (PI)
  • WESTMORELAND, SUSAN VALERIE (PI)
  • HEYES, MELVYN (PI)
  • ROSENZWEIG (PI)
  • KAUR (PI)
  • GAUDUIN, MC (PI)
  • WILLIAMS, JL (PI)
  • JOHNSON, RP (PI)
  • DUBOISE, SAMUEL MONROE (PI)
  • LEE, HEUIRAN (PI)
  • LI, MENGTAO (PI)
  • Guo, Jie (PI)
  • REITTER, JULIE (PI)
  • DESROSIERS, RONALD (PI)
  • ILYINSKII, PETR (PI)
  • HOWE, ANITA YM (PI)
  • GOULET, MARTIN (PI)
  • MADRAS, BERTHA (PI)
  • De La Garza, Richard (PI)
  • MORRIS, EVAN (PI)
  • SEHGAL, PRABHAT (PI)
  • Adams, David (PI)
  • AKITA, GEOFF (PI)
  • ASSAD, JOHN (PI)
  • BARBAS, HELEN (PI)
  • BLASDEL, GARY (PI)
  • BORN, RICHARD (PI)
  • CONNORS, JEAN (PI)
  • Diamond, Lisa (PI)
  • DOGON, LEON (PI)
  • Ferris, Craig (PI)
  • HAUSER, MARC (PI)
  • Isacson, Ole (PI)
  • LETVIN, NORMAN (PI)
  • LIBERTINI, LYN (PI)
  • LIVINGSTONE, MARGARET (PI)
  • Rakic, Pasko (PI)
  • CLAY REID (PI)
  • RHOADS, DAVID (PI)
  • ROSSINI, ALDO (PI)
  • Shapiro, Michael (PI)
  • ST GEORGE, JUDITH (PI)
  • TRAMO, MARK (PI)
  • TROILO, DAVID (PI)
  • Vatner, Dorothy (PI)
  • WANG, FRED (PI)
  • WYAND, MICHAEL (PI)
  • DE BLOIS, SANDRA (PI)
  • FOUNTAIN, ALYSSA RULF (PI)
  • JORGENSEN, MATTHEW (PI)
  • KINSEY, JANICE (PI)
  • TIEFENBACHER, STEFAN (PI)
  • MANSFIELD, KEITH (PI)
  • KOU, ZHONGCHEN (PI)
  • ROLLAND, ROSALIND (PI)
  • JOHNSON, PAUL (PI)
  • Zhang (PI)
  • ROSENZWEIG, MICHAEL (PI)
  • GAUDUIN, M-C (PI)
  • DESROSIERS, RONALD (PI)
  • CZAJAK, SUSAN (PI)
  • Mariani, Roberto (PI)
  • DESROSIERS, RONALD (PI)
  • JUNG, JAE (PI)
  • DESROSIERS, RONALD (PI)
  • LEE-PARRITZ, DAVID (PI)
  • JACKSON, LYNN (PI)
  • BARDI, MASSIMO (PI)
  • DEWS, PETER (PI)
  • MORSE, WILLIAM (PI)
  • Chen, Zheng (PI)
  • DOGON, LEON (PI)
  • GEULA, CHANGIZ (PI)
  • GWOSDOW, ANDREA (PI)
  • HAUSER, STEPHEN (PI)
  • SUSA, JOHN (PI)
  • KANAI, TAKANORI (PI)
  • CLAY REID (PI)
  • ST GEORGE, JUDITH (PI)
  • CUI, CAROL (PI)
  • Sato, Naoki (PI)
  • BARRETT-LARIMORE, RITA (PI)
  • KAUR, AMITINDER (PI)
  • YOON, DUK-WON (PI)
  • ALEXANDER, LOUIS (PI)
  • MEANS, ROBERT (PI)
  • WOOLEY, DAWN (PI)
  • FISCHMAN, ALAN (PI)
  • DESROSIERS, RONALD (PI)
  • ELLIOTT, MICHELLE (PI)
  • Galan, Jorge (PI)
  • GONZALEZ, RAMON GILBERTO (PI)
  • WANG, FREDERICK (PI)
  • TZIPORI, SAUL (PI)
  • O'NEIL, SHAWN PATRICK (PI)
  • SPEALMAN, ROGER (PI)
  • SWITZER, WILLIAM (PI)
  • NOVAK, MELINDA (PI)
  • WORTHAM, JAMES T., (PI)
  • BRAUN, STEPHEN (PI)
  • GAUDUIN, M-C (PI)
  • KOWAL, PATTY (PI)
  • RASO, VICTOR (PI)
  • LEE, BOK-SOO (PI)
  • FENG, PINGHUI (PI)
  • NAKAMURA, HIROYUKI (PI)
  • TERWILLIGER, ERNEST (PI)
  • GWAK, YOUSANG (PI)
  • CROMWELL, MARY (PI)
  • FISCHMAN, ALAN (PI)
  • GORBACH, SHERWOOD (PI)
  • DESROSIERS, RONALD (PI)
  • DESROSIERS, RONALD (PI)
  • ALDOVINI, ANNA (PI)
  • CHIOCCA, ANTONIO (PI)
  • Anderson, Carl (PI)
  • Miller, Gregory (PI)
  • YOUNG, RICHARD (PI)
  • MAKI, TAKASHI (PI)
  • MARASCO, WAYNE (PI)
  • BURRILL, THOMAS (PI)
  • FINGOLD, SYDNEY (PI)
  • KNIPE, DAVID (PI)
  • NEUTRA, MARIAN (PI)
  • REIMANN, KEITH (PI)
  • Shevitz, Abby (PI)
  • DESROSIERS, RONALD (PI)
  • Iwasaki, Akiko (PI)

Project Details

Description

Parkinson's disease (PD) is a progressive neurological disorder,
characterized by degeneration of dopamine neurons and their nerve
terminals from specific brain areas, particularly the caudate and
putamen. Since dopamine neurons contain the dopamine transporter, the
degenerative process can be monitored by the loss of the transporter
in presynaptic nerve fibers and terminals. Radioligands that bind to
these sites represent promising probes for the diagnosis and for
monitoring disease progression. We developed a novel SPECT imaging
agent, [123I]2 -carbomethoxy-3
-(4-fluorophenyl)-N-(1-iodoprop-1-en-3-yl)nortropane ([123I]
altropane) that displays favorable binding characteristics. The MPTP
model of Parkinsonism was used to evaluate the probe. Three rhesus
monkeys were imaged prior to and at 1 and 2 months after treatment
with MPTP (0.6 mg/kg administered 3 times within 10 days). The SPECT
results were correlated with scores of motor behavior and compared
with PET imaging using [11C]2 -carbomethoxy-3 -aryltropane ([11C]-CFT)
or [11C] WIN 35,428. In normal animals, striatal accumulation of
radioactivity was rapid and peak levels were achieved within 30 min.
after injection. Striatal accumulation of [123I]-altropane was nearly
fully displaceable with the dopamine transport inhibitor WIN 35,428 (1
mg/kg) but was not affected by a similar dose of the serotonin
transport inhibitor citalopram. The striatal to cerebellar ratio
measured at 30 min. after injection of [123I] altropane was
significantly higher (p < 0.01) than with [11C]-WIN 35,428; > 10:1 vs
~ 5:1. After MPTP treatment, this ratio decreased to 1:1 with [123I]
altropane and 1.5:1 with [11C]-WIN 35,428. These results demonstrate
that [123I] altropane is the first SPECT ligand for dopamine
transporter sites that combine the critical characteristics of (1)
high striatal to cerebellar ratios; (2) high selectivity for dopamine
vs. serotonin binding sites; (3) convenient preparation at high
specific activity and radiochemical purity and (4)
StatusFinished
Effective start/end date1/1/018/31/06

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