Structure-Based Engineering of Allergens to Enhance Digestibility

Project Details

Description

DESCRIPTION (provided by applicant): A crucial and unanswered question in the field of food allergy research is why certain proteins elicit an IgE mediated immune response, while others are tolerated. One compelling hypothesis is that non-allergens are more digestible, resulting in sufficient protein degradation in the stomach and intestine to render the remaining fragments immunologically inert. Despite efforts to contrast the proteolytic stability of allergens and non-allergens, a clear link between digestibility and allergenicity has yet to be established. Confounding variables such as interactions with other components in the food matrix, cross-reactivity with other allergens, or the pathway of sensitization (e.g. alimentary canal versus respiratory tract) complicate the interpretation of experimental outcomes. In this project, we develop a highly defined system for exploring the relationship between digestibility and allergenicity. We hypothesize that the digestibility of a protein is dependent on its stability under acidic (pH
StatusFinished
Effective start/end date4/1/103/31/13

Funding

  • National Institute of Allergy and Infectious Diseases: $195,000.00

ASJC

  • Medicine(all)
  • Immunology and Microbiology(all)
  • Immunology and Allergy

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