Obesity is a growing problem in the U.S. and most other countries of the world. To develop effective treatments for obesity, it is critical to understand the biology of fat storage in adipose tissue. This project investigates the functions of a protein, perilipin, which is found in fat storing cells in adipose tissue. Perilipin is the major protein surrounding the fat storing structures called lipid droplets. Perilipin functions to control the amount of fat stored during feeding, or released when energy is needed by the body. The project will study how a modification of two amino acids in perilipin affects the release of fat during the process of lipolysis. When fat is released from adipose tissue in the form of fatty acids, it is used by other tissues such as heart, muscle and liver to make energy for those tissues. In obesity, the release of fatty acids from adipose tissue is inappropriately high; these fatty acids can then be deposited in muscle, heart and liver, leading to dysfunction in these tissues, and reducing the ability of these tissues to detect insulin. The information generated by this project will be used by scientists interested in understanding how adipose tissue controls lipolysis and fatty acid release.
|Effective start/end date||10/1/11 → 9/30/16|
- National Institute of Food and Agriculture (National Institute of Food and Agriculture (NIFA))