STUDY OF ORAL HEALTH IN GREECE

Project Details

Description

The Study of Oral Health in Greece will be carried out in Athens,
Greece in collaboration with the Dr. Athanasios I. Zavras, Project
Director of the Molecular Epidemiology of Oral Cancer Study and post
doctoral fellow at the Harvard University, School of Dental Medicine,
Department of Oral Health Policy and Epidemiology. Dr. Zavras, an
oral cancer epidemiologist, has been conducting an epidemiologic
(case-control) study of oral cancer in selected hospitals in Athens,
Greece. The MEDIB is collaborating with Dr. Zavras on the molecular
and statistical analyses to be performed for this study. Risk
factors, family histories of cancer and biological samples (oral
rinses and brushings, tumor biopsy or surgical specimens (if
available) and blood spots on filter paper) will be delivered to the
MEDIB laboratory for each patient and control. The MEDIB laboratory
will apply semi-automated technologies for genetic analysis to
evaluate genes potentially responsible for oral cancer. The roles of
human papilloma virus, including interaction with and variation at
the HLA and other key chromosomal regions, will be a major focus of
the MEDIB research. In addition, molecular analyses will be conducted
to assess mutations in oncogenes and tumor suppressor genes in tumor
tissues, and polymorphic variation in metabolic detoxification
pathways among cases, controls and the baseline samples. The study
population will consist of approximately 100 cases, 100 controls plus
a baseline sample =>100.
StatusNot started

Funding

  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research

ASJC

  • Genetics
  • Dental Hygiene
  • Oncology
  • Cancer Research

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