THE DEVELOPMENT OF ANLAYTICAL PROGRAMS FOR GENETIC EPIDEMIOLOGICAL STUDIES

Project Details

Description

Gene mapping studies using DNA markers to detect craniofacial and
oral diseases utilize a wide variety of statistical techniques. We
are developing a scheme to better integrate these software tools.
Since these programs were written elsewhere using a variety of
computer languages and input for integrating them with our interval
database will streamline the analysis process. The programs include:

1) MENDEL, to calculate log adds and estimate linkage between
disease and genetic DNA marker loci,
2) affected sibling pair method
3) affected pedigree marker method
4) CRI-MAP to determine multi-point marker
5) HETERGEN - to test for linkage allowing for possible locus
heterogeneity and calculating admixture odds LOD scores
6) SIMLINK - to estimate the probability or power of detecting
linkage for a set of family pedigrees. This program simulates
cosegregation of trait and marker loci in pedigrees resulting in an
objective power calculation to determine if the collection of
families is sufficient to demonstrate linkage.
StatusNot started

Funding

  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research
  • National Institute of Dental and Craniofacial Research

ASJC

  • Genetics
  • Medicine(all)
  • Dentistry(all)
  • Statistics and Probability

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