VASCULAR PATHOLOGY IN HIV ENCEPHALITIS IN CHILDREN

Project Details

Description

Pathologic alterations of blood vessels are a common finding in
the brains of children who have died with infection due to the
retrovirus, called HIV, which causes the acquired
immunodeficiency syndrome (AIDS). Many of these children have
had clinical evidence of a progressive neurological disorder, and
there is substantial evidence to implicate HIV directly in this
encephalopathy. The present research protocol is designed to
determine the role of HIV in the pathogenesis of vascular
abnormalities in the central nervous system (CNS) of affected
children, using several complementary
techniques: immunocytochemistry, to localize HIV antigens and
to identify affected cell types, with particular reference to cells
associated with blood vessels; in situ hybridization, to determine
the location of HIV genome; and transmission electron
microscopy, to identify the relationship of viral particles to blood
vessels and to further characterize affected cell types. Attention
will also be directed to the choroid plexus and subependymal
vessels, to determine the route of entry of HIV into both the
cerebrospinal fluid and the brain, as well as to any alterations in
blood-brain barrier which might occur as a consequence of HIV
infection. The same techniques will be used in a comparative
parallel study of encephalitis in juvenile rhesus monkeys due to
the related retrovirus STLV-III. This animal model will also allow
more comprehensive study of the time course of CNS infection
due to HIV as well as of alterations in the blood-brain barrier.
Information gained from this study will be useful in devising
therapeutic strategies for this devastating CNS disorder.
StatusFinished
Effective start/end date12/31/8912/31/91

Funding

  • National Institute of Neurological Disorders and Stroke

ASJC

  • Medicine(all)
  • Neuroscience(all)
  • Clinical Neurology
  • Neurology
  • Pathology and Forensic Medicine

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