α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

Tiffany Zee; Neelanjan Bose; Jarcy Zee; Jennifer N. Beck; See Yang; Jaspreet Parihar; Min Yang; Sruthi Damodar; David Hall; Monique N. O'Leary; Arvind Ramanathan; Roy R. Gerona; David W. Killilea; Thomas Chi; Jay Tischfield; Amrik Sahota; Arnold Kahn; Marshall L. Stoller; Pankaj Kapahi

doi:10.1038/nm.4280

α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

Tiffany Zee, Neelanjan Bose, Jarcy Zee, Jennifer N. Beck, See Yang, Jaspreet Parihar, Min Yang, Sruthi Damodar, David Hall, Monique N. O'Leary, Arvind Ramanathan, Roy R. Gerona, David W. Killilea, Thomas Chi, Jay Tischfield, Amrik Sahota, Arnold Kahn, Marshall L. Stoller, Pankaj Kapahi

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1^-/- mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.

Original language	English (US)
Pages (from-to)	288-290
Number of pages	3
Journal	Nature medicine
Volume	23
Issue number	3
DOIs	https://doi.org/10.1038/nm.4280
State	Published - Mar 1 2017

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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Zee, T., Bose, N., Zee, J., Beck, J. N., Yang, S., Parihar, J., Yang, M., Damodar, S., Hall, D., O'Leary, M. N., Ramanathan, A., Gerona, R. R., Killilea, D. W., Chi, T., Tischfield, J., Sahota, A., Kahn, A., Stoller, M. L., & Kapahi, P. (2017). α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria. Nature medicine, 23(3), 288-290. https://doi.org/10.1038/nm.4280

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title = "α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria",

abstract = "Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1-/- mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.",

author = "Tiffany Zee and Neelanjan Bose and Jarcy Zee and Beck, {Jennifer N.} and See Yang and Jaspreet Parihar and Min Yang and Sruthi Damodar and David Hall and O'Leary, {Monique N.} and Arvind Ramanathan and Gerona, {Roy R.} and Killilea, {David W.} and Thomas Chi and Jay Tischfield and Amrik Sahota and Arnold Kahn and Stoller, {Marshall L.} and Pankaj Kapahi",

note = "Publisher Copyright: {\textcopyright} 2017 Nature America, Inc., part of Springer Nature.",

year = "2017",

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doi = "10.1038/nm.4280",

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Zee, T, Bose, N, Zee, J, Beck, JN, Yang, S, Parihar, J, Yang, M, Damodar, S, Hall, D, O'Leary, MN, Ramanathan, A, Gerona, RR, Killilea, DW, Chi, T, Tischfield, J , Sahota, A, Kahn, A, Stoller, ML & Kapahi, P 2017, 'α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria', Nature medicine, vol. 23, no. 3, pp. 288-290. https://doi.org/10.1038/nm.4280

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T1 - α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

AU - Zee, Tiffany

AU - Bose, Neelanjan

AU - Zee, Jarcy

AU - Beck, Jennifer N.

AU - Yang, See

AU - Parihar, Jaspreet

AU - Yang, Min

AU - Damodar, Sruthi

AU - Hall, David

AU - O'Leary, Monique N.

AU - Ramanathan, Arvind

AU - Gerona, Roy R.

AU - Killilea, David W.

AU - Chi, Thomas

AU - Tischfield, Jay

AU - Sahota, Amrik

AU - Kahn, Arnold

AU - Stoller, Marshall L.

AU - Kapahi, Pankaj

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1-/- mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.

AB - Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1-/- mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.

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α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

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