α-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

Tiffany Zee, Neelanjan Bose, Jarcy Zee, Jennifer N. Beck, See Yang, Jaspreet Parihar, Min Yang, Sruthi Damodar, David Hall, Monique N. O'Leary, Arvind Ramanathan, Roy R. Gerona, David W. Killilea, Thomas Chi, Jay Tischfield, Amrik Sahota, Arnold Kahn, Marshall L. Stoller, Pankaj Kapahi

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement α-lipoic acid inhibits cystine stone formation in the Slc3a1-/- mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.

Original languageEnglish (US)
Pages (from-to)288-290
Number of pages3
JournalNature medicine
Volume23
Issue number3
DOIs
StatePublished - Mar 1 2017

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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