β-adrenergic and cholinergic receptors in hypertension-induced hypertrophy

Dorothy E. Vatner, Debra A. Kirby, Charles J. Homcy, Stephen F. Vatner

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Perinephritic hypertension was produced in dogs by wrapping one kidney with silk and removing the contralateral kidney 1 week later. Mean arterial pressure rose from 104 ± 3 to 156 ± 11 mm Hg, while left ventricular free wall weight, normalized for body weight, was increased by 49%. Muscarinic, cholinergic receptor density measured with [3H]-quinuclidinyl benzilate, fell in hypertensive left ventricles (181 ± 19 fmol/mg, n = 6; p < 0.01) as compared with that found in normal left ventricles (272 ± 16 fmol/mg, n = 8), while receptor affinity was not changed. The β-adrenergic receptor density, measured by binding studies with [3H]-dihydroalprenolol, rose in the hypertensive left ventricles (108 ± 10 fmol/mg, n = 7; p < 0.01) as compared with that found in normal left ventricles (68.6 ± 5.2 fmol/mg, n = 15), while β-adrenergic receptor affinity decreased in the hypertensive left ventricles (10.4 ± 1.2 nM) compared with that found in the normal left ventricles (5.0 ± 0.7 nM). Plasma norepinephrine levels were similar in the two groups, but myocardial norepinephrine levels were depressed (p < 0.05) in dogs with hypertension. Moderate left ventricular hypertrophy induced by long-term aortic banding in dogs resulted in elevations in β-adrenergic receptor density (115 ± 14 fmol/mg) and decreases in affinity (10.4 ± 2.2 nM) similar to those observed in the dogs with left ventricular hypertrophy induced by hypertension. Thus, our results suggest that perinephritic hypertension in the dog induces divergent effects on cholinergic and β-adrenergic receptor density. The increased β-adrenergic receptor density and decreased affinity may be a characteristic of left ventricular hypertrophy rather than hypertension.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalHypertension
Volume7
Issue number3
StatePublished - 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Keywords

  • Muscarinic cholinergic receptor
  • Renal hypertension
  • β-adrenergic receptor

Fingerprint

Dive into the research topics of 'β-adrenergic and cholinergic receptors in hypertension-induced hypertrophy'. Together they form a unique fingerprint.

Cite this