β-adrenergic antagonists attenuate withdrawal anxiety in cocaine-and morphine-dependent rats

Glenda C. Harris, Gary Aston-Jones

Research output: Contribution to journalArticlepeer-review

99 Scopus citations

Abstract

Rats were treated chronically with either cocaine (20 mg/kg/day, 14 days), morphine (incrementing doses of 10 mg/kg/day to 80 mg/kg, 11 days) or saline. During morphine or cocaine abstinence (48 h), dependent rats showed increased anxiety-like behavior in a conditioned defensive burying paradigm as evidenced by significantly shorter latencies to begin burying as well as a 4-fold increase in burying duration relative to salinetreated animals. This withdrawal-induced increase in burying behavior was blocked by pretreatment with either the β-adrenergic antagonist propranolol (5 mg/kg) or the lipophobic selective β1-antagonist, atenolol (5 mg/kg). These results are consistent with the possibility that activation of peripheral β1 receptors may substantially contribute to withdrawal-induced anxiety and that β-adrenergic antagonists could be useful in treating in cocaine and morphine dependent addicts.

Original languageEnglish (US)
Pages (from-to)131-136
Number of pages6
JournalPsychopharmacology
Volume113
Issue number1
DOIs
StatePublished - Nov 1993
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pharmacology

Keywords

  • Atenolol
  • Beta-adrenergic antagonists
  • Cocaine
  • Conditioned defensive burying
  • Morphine dependence
  • Propranolol
  • Withdrawal

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