2,2-Dimethyl-2-(o-nitrophenyl)acetyl (DMNA) as an assisted cleavage protecting group for amines

Yongying Jiang, Jun Zhao, Longqin Hu

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

2,2-Dimethyl-2-(o-nitrophenyl)acetyl group (DMNA) was explored as an assisted cleavage protecting group for amines and a one-step deprotection condition was developed for its efficient removal using hydrogenation in the presence of Pd-C or PtO2 catalyst and 10% HOAc in MeOH. DMNA was found to be especially useful for the synthesis of gem-diamino compounds using Hofmann rearrangement.

Original languageEnglish (US)
Pages (from-to)4589-4592
Number of pages4
JournalTetrahedron Letters
Volume43
Issue number26
DOIs
Publication statusPublished - Jun 28 2002

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this