The X-ray crystal structures of the title steroidal keto acid in both its anhydrous, C22H34O3, (I), and monohydrate, C22H34O3.H2O, (II), forms have been determined. Neither hydrogen-bonding pattern involves the ketone. Compound (I) forms infinite carboxyl-to-carboxyl hydrogen-bonding chains. This is the first observed case of a keto carboxylic acid forming such an acid-to-acid catemer. In (II), each carboxyl is hydrogen bonded to three water molecules and each water forms hydrogen bonds with carboxyl groups from three steroid molecules, creating a network of connected ten-membered hydrogen-bonding rings.
|Original language||English (US)|
|Number of pages||4|
|Journal||Acta Crystallographica Section C: Crystal Structure Communications|
|State||Published - Mar 15 1998|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)