A balancing act: mTOR integrates nutrient signals to regulate redox-dependent growth and survival through SOD1

Chi Kwan Tsang; X. F.Steven Zheng

doi:10.1080/23723556.2018.1488372

A balancing act: mTOR integrates nutrient signals to regulate redox-dependent growth and survival through SOD1

Chi Kwan Tsang, X. F.Steven Zheng

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

Maintaining cellular redox is critical for growth, metabolism and survival in response to changing environments. How nutrients regulate this process is a long-standing fundamental question in cell biology. Our recent study revealed a conserved mechanism by which eukaryotes, particularly cancer cells, couple nutrient signaling to dynamically regulate redox homeostasis. Abbreviations: ATP: adenosine triphosphate; Ala: alanine; C₆H₁₂O₆: glucose; OH⁻: hydroxyl radical; Glu: glutamate; mRNA: messenger RNA; mTOR: mechanistic/mammalian target of rapamycin; OXYPHOS: oxidative phosphorylation; Ser: serine; ROS: reactive oxygen species; O₂ ⁻: superoxide; SOD1: superoxide dismutase 1; Thr: threonine.

Original language	English (US)
Article number	e1488372
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1080/23723556.2018.1488372
State	Published - Sep 3 2018

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

Keywords

ROS
SOD1
ischemia
mTOR
nutrient

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10.1080/23723556.2018.1488372

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abstract = "Maintaining cellular redox is critical for growth, metabolism and survival in response to changing environments. How nutrients regulate this process is a long-standing fundamental question in cell biology. Our recent study revealed a conserved mechanism by which eukaryotes, particularly cancer cells, couple nutrient signaling to dynamically regulate redox homeostasis. Abbreviations: ATP: adenosine triphosphate; Ala: alanine; C6H12O6: glucose; OH−: hydroxyl radical; Glu: glutamate; mRNA: messenger RNA; mTOR: mechanistic/mammalian target of rapamycin; OXYPHOS: oxidative phosphorylation; Ser: serine; ROS: reactive oxygen species; O2 −: superoxide; SOD1: superoxide dismutase 1; Thr: threonine.",

keywords = "ROS, SOD1, ischemia, mTOR, nutrient",

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AU - Zheng, X. F.Steven

N1 - Funding Information: This work was supported by the National Institutes of Health [R01CA166575];National Institutes of Health [R01CA123391]; Publisher Copyright: © 2018, © 2018 Taylor & Francis Group, LLC.

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Y1 - 2018/9/3

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KW - ischemia

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A balancing act: mTOR integrates nutrient signals to regulate redox-dependent growth and survival through SOD1

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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