TY - GEN
T1 - A Bioelectronic Hand-Held Spectrophotometer for Biospecimen Analysis for Global Health Applications
AU - Hooda, Pragya
AU - Tekin, Omer F.
AU - Sami, Muhammad A.
AU - Hassan, Umer
N1 - Funding Information:
* This research is supported by Rutgers School of Engineering, Global Health Institute and Research Council Award by Rutgers, The State University of New Jersey.
Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - Patients suffering with bacterial infections are commonly prescribed antibiotic drugs for a certain period until their treatment is complete. Utilizing patient's bio fluid samples (e.g., blood or urine), we can quantify the antibiotic levels to understand its effective absorption. Laboratory spectrophotometer is normally used as a gold standard instrument to perform such analysis by measuring light absorption through a sample solution in real-time. Here, we have developed a 3D printed Point-of-Care (POC) device that can be used to detect the concentration of proteins in biological samples. We quantified Bovine Serum Albumin (BSA) concentration using a Bradford protein assay to test the 3D printed device efficacy against an instrument spectrophotometer and obtained a correlation co-efficient of R2 = 0.989 between the two methods. Our results show the potential of our 3D printed spectrophotometer to quantify other proteins and specific antibiotics (e.g., Rifampin for Tuberculosis management) to monitor and manage patients' treatment.
AB - Patients suffering with bacterial infections are commonly prescribed antibiotic drugs for a certain period until their treatment is complete. Utilizing patient's bio fluid samples (e.g., blood or urine), we can quantify the antibiotic levels to understand its effective absorption. Laboratory spectrophotometer is normally used as a gold standard instrument to perform such analysis by measuring light absorption through a sample solution in real-time. Here, we have developed a 3D printed Point-of-Care (POC) device that can be used to detect the concentration of proteins in biological samples. We quantified Bovine Serum Albumin (BSA) concentration using a Bradford protein assay to test the 3D printed device efficacy against an instrument spectrophotometer and obtained a correlation co-efficient of R2 = 0.989 between the two methods. Our results show the potential of our 3D printed spectrophotometer to quantify other proteins and specific antibiotics (e.g., Rifampin for Tuberculosis management) to monitor and manage patients' treatment.
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U2 - 10.1109/HI-POCT54491.2022.9744058
DO - 10.1109/HI-POCT54491.2022.9744058
M3 - Conference contribution
AN - SCOPUS:85128639321
T3 - Healthcare Innovations and Point of Care Technologies Conference, HI-POCT 2022
SP - 99
EP - 102
BT - Healthcare Innovations and Point of Care Technologies Conference, HI-POCT 2022
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2022 IEEE-EMB Special Topic Conference on Healthcare Innovations and Point of Care Technologies, HI-POCT 2022
Y2 - 10 March 2022 through 11 March 2022
ER -