A blinded study of the suppressibility of involuntary movements in Huntington's chorea, tardive dyskinesia, and L-DOPA-induced chorea

A. S. Walters, D. McHale, J. I. Sage, W. A. Hening, M. Bergen

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Videotapes of patients with Huntington's chorea, tardive dyskinesia (TD), and L-DOPA-induced chorea in Parkinson's disease were taken while the patients were seated with their legs dangling. The videotapes were scored in a blinded fashion for suppressibility of dyskinesias. Most patients with TD or L-DOPA-induced chorea substantially suppressed their involuntary movements, whereas most patients with Huntington's chorea did not. There was a small overlap between the TD and Huntington's chorea groups and suppressibility therefore could not absolutely distinguish between them. Suppressibility testing may nonetheless be a valuable clinical tool since a good, excellent, or complete suppressibility rating was highly suggestive of TD but not Huntington's chorea. TD and L-DOPA-induced chorea may be more pathophysiologically similar to each other than either is to Huntington's chorea.

Original languageEnglish (US)
Pages (from-to)236-240
Number of pages5
JournalClinical Neuropharmacology
Volume13
Issue number3
DOIs
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

Keywords

  • Huntington's chorea
  • L-DOPA-induced chorea
  • Parkinson's disease
  • suppressibility
  • tardive dyskinesia

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