A combined linkage-physical map of the human genome

X. Kong, K. Murphy, T. Raj, C. He, P. S. White, Tara C. Matise

Research output: Contribution to journalArticlepeer-review

192 Scopus citations

Abstract

We have constructed de novo a high-resolution genetic map that includes the largest set, to our knowledge, of polymorphic markers (N = 14,759) for which genotype data are publicly available; that combines genotype data from both the Centre d'Etude du Polymorphisme Humain (CEPH) and deCODE pedigrees; that incorporates single-nucleotide polymorphisms; and that also incorporates sequence-based positional information. The position of all markers on our map is corroborated by both genomic sequence and recombination-based data. This specific combination of features maximizes marker inclusion, coverage, and resolution, making this map uniquely suitable as a comprehensive resource for determining genetic map information (order and distances) for any large set of polymorphic markers.

Original languageEnglish (US)
Pages (from-to)1143-1148
Number of pages6
JournalAmerican Journal of Human Genetics
Volume75
Issue number6
DOIs
StatePublished - Dec 2004

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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