A comparative kinetics study of monochloramine and hypochlorous acid in rat

M. S. Abdel‐Rahman, Doreen Waldron Lechner, R. J. Bull

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The problem of trihalomethane formation now exists with the use of chlorine (technically, a mixture of HOCl and OCl, depending on pH) as a disinfectant in drinking water. Monochloramine (NH2Cl) may be considered as an alternative to HOCl as a disinfectant in public water supplies. This study was conducted to compare the kinetics of NH236Cl with HO36Cl in rats. The peak plasma levels of 36Cl occurred at 8 and 2 h for NH236Cl and HO36Cl, respectively. The distribution of NH236Cl and HO36Cl was highest in plasma, while the lowest activity was observed in the fat. The half‐life for 36Cl absorption was 2.49 and 2.16 h, while the elimination from plasma was 38.8 and 44.1 h after oral NH236Cl and HO36Cl treatment, respectively. Urinary excretion accounted for most of the 36Cl eliminated in both treatments.

Original languageEnglish (US)
Pages (from-to)175-179
Number of pages5
JournalJournal of Applied Toxicology
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1983

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Hypochlorous Acid
Rats
Disinfectants
Plasmas
Kinetics
Trihalomethanes
Water Supply
Chlorine
Water supply
Drinking Water
Half-Life
Fats
chloramine

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

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A comparative kinetics study of monochloramine and hypochlorous acid in rat. / Abdel‐Rahman, M. S.; Waldron Lechner, Doreen; Bull, R. J.

In: Journal of Applied Toxicology, Vol. 3, No. 4, 01.01.1983, p. 175-179.

Research output: Contribution to journalArticle

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