A comparative kinetics study of monochloramine and hypochlorous acid in rat

M. S. Abdel‐Rahman; D. M. Waldron; R. J. Bull

doi:10.1002/jat.2550030403

A comparative kinetics study of monochloramine and hypochlorous acid in rat

M. S. Abdel‐Rahman, D. M. Waldron, R. J. Bull

School of Health Professions, Biomedical Informatics

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The problem of trihalomethane formation now exists with the use of chlorine (technically, a mixture of HOCl and OCl⁻, depending on pH) as a disinfectant in drinking water. Monochloramine (NH₂Cl) may be considered as an alternative to HOCl as a disinfectant in public water supplies. This study was conducted to compare the kinetics of NH₂³⁶Cl with HO³⁶Cl in rats. The peak plasma levels of ³⁶Cl occurred at 8 and 2 h for NH₂³⁶Cl and HO³⁶Cl, respectively. The distribution of NH₂³⁶Cl and HO³⁶Cl was highest in plasma, while the lowest activity was observed in the fat. The half‐life for ³⁶Cl absorption was 2.49 and 2.16 h, while the elimination from plasma was 38.8 and 44.1 h after oral NH₂³⁶Cl and HO³⁶Cl treatment, respectively. Urinary excretion accounted for most of the ³⁶Cl eliminated in both treatments.

Original language	English (US)
Pages (from-to)	175-179
Number of pages	5
Journal	Journal of Applied Toxicology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1002/jat.2550030403
State	Published - Aug 1983

All Science Journal Classification (ASJC) codes

Toxicology

Keywords

disinfectants
hypochlorous acid
kinetics
monochloramine

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10.1002/jat.2550030403

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title = "A comparative kinetics study of monochloramine and hypochlorous acid in rat",

abstract = "The problem of trihalomethane formation now exists with the use of chlorine (technically, a mixture of HOCl and OCl−, depending on pH) as a disinfectant in drinking water. Monochloramine (NH2Cl) may be considered as an alternative to HOCl as a disinfectant in public water supplies. This study was conducted to compare the kinetics of NH236Cl with HO36Cl in rats. The peak plasma levels of 36Cl occurred at 8 and 2 h for NH236Cl and HO36Cl, respectively. The distribution of NH236Cl and HO36Cl was highest in plasma, while the lowest activity was observed in the fat. The half‐life for 36Cl absorption was 2.49 and 2.16 h, while the elimination from plasma was 38.8 and 44.1 h after oral NH236Cl and HO36Cl treatment, respectively. Urinary excretion accounted for most of the 36Cl eliminated in both treatments.",

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AU - Waldron, D. M.

AU - Bull, R. J.

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N2 - The problem of trihalomethane formation now exists with the use of chlorine (technically, a mixture of HOCl and OCl−, depending on pH) as a disinfectant in drinking water. Monochloramine (NH2Cl) may be considered as an alternative to HOCl as a disinfectant in public water supplies. This study was conducted to compare the kinetics of NH236Cl with HO36Cl in rats. The peak plasma levels of 36Cl occurred at 8 and 2 h for NH236Cl and HO36Cl, respectively. The distribution of NH236Cl and HO36Cl was highest in plasma, while the lowest activity was observed in the fat. The half‐life for 36Cl absorption was 2.49 and 2.16 h, while the elimination from plasma was 38.8 and 44.1 h after oral NH236Cl and HO36Cl treatment, respectively. Urinary excretion accounted for most of the 36Cl eliminated in both treatments.

AB - The problem of trihalomethane formation now exists with the use of chlorine (technically, a mixture of HOCl and OCl−, depending on pH) as a disinfectant in drinking water. Monochloramine (NH2Cl) may be considered as an alternative to HOCl as a disinfectant in public water supplies. This study was conducted to compare the kinetics of NH236Cl with HO36Cl in rats. The peak plasma levels of 36Cl occurred at 8 and 2 h for NH236Cl and HO36Cl, respectively. The distribution of NH236Cl and HO36Cl was highest in plasma, while the lowest activity was observed in the fat. The half‐life for 36Cl absorption was 2.49 and 2.16 h, while the elimination from plasma was 38.8 and 44.1 h after oral NH236Cl and HO36Cl treatment, respectively. Urinary excretion accounted for most of the 36Cl eliminated in both treatments.

KW - disinfectants

KW - hypochlorous acid

KW - kinetics

KW - monochloramine

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A comparative kinetics study of monochloramine and hypochlorous acid in rat

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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