@article{f1e73026de154cce8c6d2669731ab93e,
title = "A comprehensive and contemporary “snapshot” of β-lactamases in carbapenem resistant Acinetobacter baumannii",
abstract = "Successful treatment of Acinetobacter baumannii infections require early and appropriate antimicrobial therapy. One of the first steps in this process is understanding which β-lactamase (bla) alleles are present and in what combinations. Thus, we performed WGS on 98 carbapenem-resistant A. baumannii (CR Ab). In most isolates, an acquired blaOXA carbapenemase was found in addition to the intrinsic blaOXA allele. The most commonly found allele was blaOXA-23 (n = 78/98). In some isolates, blaOXA-23 was found in addition to other carbapenemase alleles: blaOXA-82 (n = 12/78), blaOXA-72 (n = 2/78) and blaOXA-24/40 (n = 1/78). Surprisingly, 20% of isolates carried carbapenemases not routinely assayed for by rapid molecular diagnostic platforms, i.e., blaOXA-82 and blaOXA-172; all had ISAba1 elements. In 8 CR Ab, blaOXA-82 or blaOXA-172 was the only carbapenemase. Both blaOXA-24/40 and its variant blaOXA-72 were each found in 6/98 isolates. The most prevalent ADC variants were blaADC-30 (21%), blaADC-162 (21%), and blaADC-212 (26%). Complete combinations are reported.",
keywords = "ADC β-lactamase, Carbapenem resistant Acinetobacter baumannii, OXA carbapenemase, OXA-172, OXA-23, OXA-82",
author = "{for the Antibacterial Resistance Leadership Group (ARLG)} and Hujer, {Andrea M.} and Hujer, {Kristine M.} and Leonard, {David A.} and Powers, {Rachel A.} and Wallar, {Bradley J.} and Mack, {Andrew R.} and Taracila, {Magdalena A.} and Rather, {Philip N.} and Higgins, {Paul G.} and Fabio Prati and Emilia Caselli and Marshall, {Steven H.} and Thomas Clarke and Christopher Greco and Pratap Venepally and Lauren Brinkac and Kreiswirth, {Barry N.} and Fouts, {Derrick E.} and Bonomo, {Robert A.}",
note = "Funding Information: Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIH) to R.A.B. under Award Numbers R01AI100560 , R01AI063517 , and R01AI072219 , and has been funded in part with federal funds from the National Institute of Allergy and Infectious Diseases of the NIH , Department of Health and Human Services under Award Number U19AI110819. P.N.R. is supported by funding from the U.S. Department of Veterans Affairs I01 BX001725 , IK6BX004470 and NIH awards R21AI142489 and R01AI072219 . This study was also supported in part by funds and/or facilities provided by the Cleveland Department of Veterans Affairs , Award Number 1I01BX001974 to R.A.B. from the Biomedical Laboratory Research & Development Service of the VA Office of Research and Development, and the Geriatric Research Education and Clinical Center VISN 10. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH or the Department of Veterans Affairs. Publisher Copyright: {\textcopyright} 2020",
year = "2021",
month = feb,
doi = "10.1016/j.diagmicrobio.2020.115242",
language = "English (US)",
volume = "99",
journal = "Diagnostic Microbiology and Infectious Disease",
issn = "0732-8893",
publisher = "Elsevier Inc.",
number = "2",
}