A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome-wide significant common variants

Sehee Kim, Miao Wang, Jonathan P. Tyrer, Allan Jensen, Ashley Wiensch, Gang Liu, Alice W. Lee, Roberta B. Ness, Maxwell Salvatore, Shelley S. Tworoger, Alice S. Whittemore, Hoda Anton-Culver, Weiva Sieh, Sara H. Olson, Andrew Berchuck, Ellen L. Goode, Marc T. Goodman, Jennifer Anne Doherty, Georgia Chenevix-Trench, Mary Anne RossingPenelope M. Webb, Graham G. Giles, Kathryn L. Terry, Argyrios Ziogas, Renée T. Fortner, Usha Menon, Simon A. Gayther, Anna H. Wu, Honglin Song, Angela Brooks-Wilson, Elisa Bandera, Linda S. Cook, Daniel W. Cramer, Roger L. Milne, Stacey J. Winham, Susanne K. Kjaer, Francesmary Modugno, Pamela J. Thompson, Jenny Chang-Claude, Holly R. Harris, Joellen M. Schildkraut, Nhu D. Le, Nico Wentzensen, Britton Trabert, Estrid Høgdall, David Huntsman, Malcolm C. Pike, Paul D.P. Pharoah, Celeste Leigh Pearce, Bhramar Mukherjee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), our study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variants. The interaction analyses were based on data from 9971 ovarian cancer cases and 15,566 controls from 17 case–control studies. Likelihood ratio and Wald tests for multiplicative interaction and for relative excess risk due to additive interaction were used. The top multiplicative interaction was noted between oral contraceptive pill (OCP) use (ever vs. never) and rs13255292 (p value = 3.48 × 10 −4 ). Among women with the TT genotype for this variant, the odds ratio for OCP use was 0.53 (95% CI = 0.46–0.60) compared to 0.71 (95%CI = 0.66–0.77) for women with the CC genotype. When stratified by duration of OCP use, women with 1–5 years of OCP use exhibited differential protective benefit across genotypes. However, no interaction on either the multiplicative or additive scale was found to be statistically significant after multiple testing correction. The results suggest that OCP use may offer increased benefit for women who are carriers of the T allele in rs13255292. On the other hand, for women carrying the C allele in this variant, longer (5+ years) use of OCP may reduce the impact of carrying the risk allele of this SNP. Replication of this finding is needed. The study presents a comprehensive analytic framework for conducting gene–environment analysis in ovarian cancer.

Original languageEnglish (US)
Pages (from-to)2192-2205
Number of pages14
JournalInternational Journal of Cancer
Volume144
Issue number9
DOIs
StatePublished - May 1 2019

Fingerprint

Oral Contraceptives
Ovarian Neoplasms
Genome
Alleles
Genotype
Genome-Wide Association Study
Single Nucleotide Polymorphism
Odds Ratio
Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Keywords

  • G × E
  • additive interaction
  • genetics
  • ovarian cancer

Cite this

Kim, Sehee ; Wang, Miao ; Tyrer, Jonathan P. ; Jensen, Allan ; Wiensch, Ashley ; Liu, Gang ; Lee, Alice W. ; Ness, Roberta B. ; Salvatore, Maxwell ; Tworoger, Shelley S. ; Whittemore, Alice S. ; Anton-Culver, Hoda ; Sieh, Weiva ; Olson, Sara H. ; Berchuck, Andrew ; Goode, Ellen L. ; Goodman, Marc T. ; Doherty, Jennifer Anne ; Chenevix-Trench, Georgia ; Rossing, Mary Anne ; Webb, Penelope M. ; Giles, Graham G. ; Terry, Kathryn L. ; Ziogas, Argyrios ; Fortner, Renée T. ; Menon, Usha ; Gayther, Simon A. ; Wu, Anna H. ; Song, Honglin ; Brooks-Wilson, Angela ; Bandera, Elisa ; Cook, Linda S. ; Cramer, Daniel W. ; Milne, Roger L. ; Winham, Stacey J. ; Kjaer, Susanne K. ; Modugno, Francesmary ; Thompson, Pamela J. ; Chang-Claude, Jenny ; Harris, Holly R. ; Schildkraut, Joellen M. ; Le, Nhu D. ; Wentzensen, Nico ; Trabert, Britton ; Høgdall, Estrid ; Huntsman, David ; Pike, Malcolm C. ; Pharoah, Paul D.P. ; Pearce, Celeste Leigh ; Mukherjee, Bhramar. / A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome-wide significant common variants. In: International Journal of Cancer. 2019 ; Vol. 144, No. 9. pp. 2192-2205.
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abstract = "As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), our study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variants. The interaction analyses were based on data from 9971 ovarian cancer cases and 15,566 controls from 17 case–control studies. Likelihood ratio and Wald tests for multiplicative interaction and for relative excess risk due to additive interaction were used. The top multiplicative interaction was noted between oral contraceptive pill (OCP) use (ever vs. never) and rs13255292 (p value = 3.48 × 10 −4 ). Among women with the TT genotype for this variant, the odds ratio for OCP use was 0.53 (95{\%} CI = 0.46–0.60) compared to 0.71 (95{\%}CI = 0.66–0.77) for women with the CC genotype. When stratified by duration of OCP use, women with 1–5 years of OCP use exhibited differential protective benefit across genotypes. However, no interaction on either the multiplicative or additive scale was found to be statistically significant after multiple testing correction. The results suggest that OCP use may offer increased benefit for women who are carriers of the T allele in rs13255292. On the other hand, for women carrying the C allele in this variant, longer (5+ years) use of OCP may reduce the impact of carrying the risk allele of this SNP. Replication of this finding is needed. The study presents a comprehensive analytic framework for conducting gene–environment analysis in ovarian cancer.",
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Kim, S, Wang, M, Tyrer, JP, Jensen, A, Wiensch, A, Liu, G, Lee, AW, Ness, RB, Salvatore, M, Tworoger, SS, Whittemore, AS, Anton-Culver, H, Sieh, W, Olson, SH, Berchuck, A, Goode, EL, Goodman, MT, Doherty, JA, Chenevix-Trench, G, Rossing, MA, Webb, PM, Giles, GG, Terry, KL, Ziogas, A, Fortner, RT, Menon, U, Gayther, SA, Wu, AH, Song, H, Brooks-Wilson, A, Bandera, E, Cook, LS, Cramer, DW, Milne, RL, Winham, SJ, Kjaer, SK, Modugno, F, Thompson, PJ, Chang-Claude, J, Harris, HR, Schildkraut, JM, Le, ND, Wentzensen, N, Trabert, B, Høgdall, E, Huntsman, D, Pike, MC, Pharoah, PDP, Pearce, CL & Mukherjee, B 2019, 'A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome-wide significant common variants', International Journal of Cancer, vol. 144, no. 9, pp. 2192-2205. https://doi.org/10.1002/ijc.32029

A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome-wide significant common variants. / Kim, Sehee; Wang, Miao; Tyrer, Jonathan P.; Jensen, Allan; Wiensch, Ashley; Liu, Gang; Lee, Alice W.; Ness, Roberta B.; Salvatore, Maxwell; Tworoger, Shelley S.; Whittemore, Alice S.; Anton-Culver, Hoda; Sieh, Weiva; Olson, Sara H.; Berchuck, Andrew; Goode, Ellen L.; Goodman, Marc T.; Doherty, Jennifer Anne; Chenevix-Trench, Georgia; Rossing, Mary Anne; Webb, Penelope M.; Giles, Graham G.; Terry, Kathryn L.; Ziogas, Argyrios; Fortner, Renée T.; Menon, Usha; Gayther, Simon A.; Wu, Anna H.; Song, Honglin; Brooks-Wilson, Angela; Bandera, Elisa; Cook, Linda S.; Cramer, Daniel W.; Milne, Roger L.; Winham, Stacey J.; Kjaer, Susanne K.; Modugno, Francesmary; Thompson, Pamela J.; Chang-Claude, Jenny; Harris, Holly R.; Schildkraut, Joellen M.; Le, Nhu D.; Wentzensen, Nico; Trabert, Britton; Høgdall, Estrid; Huntsman, David; Pike, Malcolm C.; Pharoah, Paul D.P.; Pearce, Celeste Leigh; Mukherjee, Bhramar.

In: International Journal of Cancer, Vol. 144, No. 9, 01.05.2019, p. 2192-2205.

Research output: Contribution to journalArticle

TY - JOUR

T1 - A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome-wide significant common variants

AU - Kim, Sehee

AU - Wang, Miao

AU - Tyrer, Jonathan P.

AU - Jensen, Allan

AU - Wiensch, Ashley

AU - Liu, Gang

AU - Lee, Alice W.

AU - Ness, Roberta B.

AU - Salvatore, Maxwell

AU - Tworoger, Shelley S.

AU - Whittemore, Alice S.

AU - Anton-Culver, Hoda

AU - Sieh, Weiva

AU - Olson, Sara H.

AU - Berchuck, Andrew

AU - Goode, Ellen L.

AU - Goodman, Marc T.

AU - Doherty, Jennifer Anne

AU - Chenevix-Trench, Georgia

AU - Rossing, Mary Anne

AU - Webb, Penelope M.

AU - Giles, Graham G.

AU - Terry, Kathryn L.

AU - Ziogas, Argyrios

AU - Fortner, Renée T.

AU - Menon, Usha

AU - Gayther, Simon A.

AU - Wu, Anna H.

AU - Song, Honglin

AU - Brooks-Wilson, Angela

AU - Bandera, Elisa

AU - Cook, Linda S.

AU - Cramer, Daniel W.

AU - Milne, Roger L.

AU - Winham, Stacey J.

AU - Kjaer, Susanne K.

AU - Modugno, Francesmary

AU - Thompson, Pamela J.

AU - Chang-Claude, Jenny

AU - Harris, Holly R.

AU - Schildkraut, Joellen M.

AU - Le, Nhu D.

AU - Wentzensen, Nico

AU - Trabert, Britton

AU - Høgdall, Estrid

AU - Huntsman, David

AU - Pike, Malcolm C.

AU - Pharoah, Paul D.P.

AU - Pearce, Celeste Leigh

AU - Mukherjee, Bhramar

PY - 2019/5/1

Y1 - 2019/5/1

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