A convenient biphasic process for the monosilylation of symmetrical 1,n- primary diols

Chengzhi Yu, Bin Liu, Longqin Hu

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A simple and mild biphasic process was developed for the selective protection of one of two chemically equivalent primary hydroxyl groups in 1,n-diols using t-butyldiphenyl silyl chloride in diisopropyl ethyl amine and dimethyl formamide. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)4281-4285
Number of pages5
JournalTetrahedron Letters
Volume41
Issue number22
DOIs
StatePublished - Jun 8 2000

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Keywords

  • 1,n-diol
  • Biphasic
  • Selective protection
  • Silylation

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