A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

Kamana Misra, Michael P. Matise

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Both the BMP and Wnt pathways have been implicated in directing aspects of dorsal neural tube closure and cell fate specification. However, the mechanisms that control the diverse responses to these signals are poorly understood. In this study, we provide genetic and functional evidence that the secreted sFRP1 and sFRP2 proteins, which have been primarily implicated as negative regulators of Wnt signaling, can also antagonize BMP signaling in the caudal neural tube and that this function is critical to maintain proper neural tube closure and dorsal cell fate segregation. Our studies thus reveal a novel role for specific sFRP proteins in balancing the response of cells to two critical extracellular signaling pathways.

Original languageEnglish (US)
Pages (from-to)74-83
Number of pages10
JournalDevelopmental Biology
Volume337
Issue number1
DOIs
StatePublished - Jan 1 2010

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Keywords

  • BMP signaling
  • Neural tube closure
  • Signal integration
  • Wnt signaling
  • sFRP1
  • sFRP2

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